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June 17, 2016   

Investigators and Clinicians: CTN-0071 Needs You!



0071Ot iconCTN-0071-Ot, the Electronic Health Records Data Elements Research Study (EHR-DARE), will be launching this summer through the Mid-Southern Node.

This innovative research project aims to identify EHR data available at healthcare facilities associated with the CTN, with an overarching goal to address barriers to progress in substance use disorder (SUD) research.

Project staff hope to bridge the gap between desired and available EHR data through two aims of recruitment:

  • Aim 1 will identify data needed to answer research questions of importance to advancing SUD screening, intervention, and treatment-related efforts. Investigators will receive an email with a link to the study’s private survey.

  • Aim 2 will consist of two waves to identify and characterize EHR data current available at CTN participating health care facilities:

    • Wave 1 will include another web-based survey, designed for clinicians at each of the health care facilities associated with CTN Nodes;

    • Wave 2 will involve phone interviews with providers regarding specific scenarios within their EHR program.

The EHR-DARE study is project to begin in late summer or early fall 2016, and hopes to utilize local Node Coordinators for recruitment assistance. Please be on the lookout for updates coming from the Mid Southern Node throughout the summer!

Any questions can be forwarded to Micki Roseman, Mid Southern Node Coordinator (kimberly.roseman@duke.edu); Li-Tzy Wu, ScD., Mid Southern Node PI (litzy-wu@duke.edu); or Mary Williams CTN0071 Project Lead (mary.williams2@duke.edu).

CTN Trial Progress

Study results for Open Studies as of the June 16 trial Progress Report.

CTN-0050 - Long Term Follow-up to the CTN-0027 (START) Study: Enrolled 877 (original N=1,267 START Study participants)

CTN-0051 - X-BOT (Extended Release Naltrexone vs. Buprenorphine for Opioid Treatment). Enrolled 570

CTN-0056-Ot - Testing and Linkage to HIV Care in China. Enrolled 478

CTN-0057-Ot - SBIRT-PC (SBIRT in Primary Care). Enrolled 108 (N=120)

CTN-0064 - Linkage to HCV Care. Enrolled 31

Total Enrolled in all Studies: 23,836

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X:BOT Completes Recruitment!

X:BOTThe Lead Team is delighted to announce that CTN-0051 (X:BOT) met its recruitment goal on Friday, May 20, 2016 with the final participant randomized on May 25th. Final numbers are: 772 consented and 570 randomized; 352 “late” randomizers (those randomized more than 72 hours following their last opioid).

Participants remain in treatment for 24 weeks, with follow-up at week 28 and at week 36. The team anticipates the final follow up visit will be in February 2017, with data lock in May 2017.

The Lead Node thanks the Site teams, the Emmes CCC and DSC, and the NIDA CCTN for all their hard work getting to this study milestone! Read more. . .

Meet the X:BOT Tots!

As if meeting recruitment goals weren't exciting enough, the CTN-0051 study team also has some other "outcomes" to report: a fresh batch of very new, very small X:BOT staffers! (Be sure to notice their awesome "X:BOT TOT" robot onesies!)

Left to right: Nik (Josh Lee), Isabel (Elly Patterson-Bhatraju), and Kiyo (Sarah Meyers-Ohki).

Congratulations, expanding X:BOT family!

Nik Isabel Kiyo

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News from the Northeast Node

The CTN Northeast Node is pleased to announce their participation in a National Drug Early Warning Systems (NDEWS) “Hot Spot” study.

NDEWS is a NIDA-funded cooperative agreement with the University of Maryland’s Center for Substance Abuse Research (CESAR). NDEWS is charged with monitoring drug abuse trends and targeting specific “hot spots” of drug abuse via on-the-ground investigation to enable public health officials to respond quickly to potential outbreaks in their local communities.

According to reports from the New Hampshire Drug Monitoring Initiative for February, March, and April 2016, NH experienced recent increases in both drug overdose deaths and opioid-related emergency department visits. Nearly two-thirds of New Hampshire overdose deaths in 2015 involved fentanyl.

NDEWS will be sending a team to NH in early July 2016 to assist in characterizing this recent fentanyl outbreak in a 1-week Hot Spot study. The Northeast Node is facilitating connections with our NH Node partners and local experts for this study and will help with study data collection and dissemination.

Read more. . .

New from the Addiction Technology Transfer Center (ATTC) Network

The 2016 NFAR Technology Summit will take technology-assisted care to the next level by focusing on how digital health technologies can be used to address health disparities and close the gap for individuals who face barriers to accessing substance use treatment and recovery services. Register now for the 2016 NFAR ATTC Technology Summit, Philadelphia, PA, August 3-5, 2016.

This month's featured article in the ATTC Messenger examines the Art and Science of Using Technologies to Intervene, Treat, and Support Individuals with Substance Use Disorders. The CTN Research Briefs this month focus on articles about CTN-0044 and CTN-0073-Ot, both of which also address the use of technology in clinical trials.

As always, don’t miss the great content from the ATTC/NIATx Service Improvement Blog!

Read more. . .

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DI Conf

The 9th Annual Conference on the Science of Dissemination and Implementation, co-hosted by the National Institutes of Health and Academy Health, will be held December 14-15, 2016, in Washington, DC.

Abstract submission is now open -- submit yours no later than August 4th to be considered for inclusion in the program!

Nine thematic tracks have been identified for this year's program: Behavioral Health; Big Data and Technology; Clinical Care Settings; Global Dissemination & Implementation; Health Policy Dissemination & Implementation; Models; Measures; and Methods; Precision Medicine; Prevention & Public Health; and Promoting Health Equity and Eliminating Disparities. Read more. . .

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New from the CTN Dissemination Library

Barriers and Facilitators to Tobacco Cessation in a Nationwide Sample of Addiction Treatment Programs. Pagano A, et al. J Subst Abuse Treat 2016;67:22-29. Read more. . .

A Comparison of African American and Caucasian Stimulant Users in 12-Step Facilitation Treatment. Peavy KM, et al. J Ethnicity Subst Abuse 2016 (in press). Read more. . .

Also of interest:
Improving the value of clinical research through the use of Common Data Elements. Sheehan J, et al. Clinical Trials 2016 (in press). Read more. . .

More New in the Library. . .

SAMHDA: Source for Secondary Data

The enhanced Substance Abuse and Mental Health Data Archive (SAMHDA) is back online with new features and a new URL: http://datafiles.samhsa.gov.

CTN Researchers: SAMHDA is a data source to consider for the recent NIH Program Announcement on "Accelerating the Pace of Drug Abuse Research Using Existing Data (R01)" (PAR-16-234). NIDA, NIAAA, and NCI are all participating in the funding program.

In late summer 2016, the SAMHDA website will add a user-friendly, online analysis tool. Users will be able to create cross-tabs and perform logistic regression, chi-square tests, and t-tests from their web browsers. They will also be able to download output and underlying data in .csv format. A secure data portal will be added in early winter 2016 as well. Read more . . .

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News from Emmes (CTN Data & Statistics Center and Clinical Coordinating Center)

EMMES logoThe CTN Data & Statistics Center (DSC) will be launching a new CTN website later this summer. This new website will replace the current http://ctndsc2.com/, including the Trial Progress and Data Status Reports. All study documents will be posted on the new website, which will eventually also replace Livelink. CTN Staff with existing website access will be sent access information and instructions on updating user profiles. As always, questions can be directed to nidadsc2help@emmes.com.  

SCT logoIn other Emmes staff news, 10 abstracts from DSC and Clinical Coordinating Center staff were included at the 37th Annual Meeting of the Society for Clinical Trials this past May. The meeting was well attended by experts and professionals from academia, the pharmaceutical and device industries, government agencies, and clinical research entities.

DSC and CCC staff presented at the preconference workshops and contributed paper sessions at well. Click here for a list of the presentations and authors; please reach out to the presenters if you'd like to learn more about any of the topics!

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From the CCC and CCTN

From the Clinical Coordinating Center: Dissemination and Implementation Research in Health (DIRH) Program Announcements: R01, R21, R03.

See also this National Cancer Institute webinar introducing Program Announcements in Dissemination and Implementation Research in Health. (Next webinar in this series coming Fall 2016.)

From the Center for the Clinical Trials Network: All CCTN staff will be getting new phone numbers. The old numbers are still operational, but will soon be deactivated. Find the new numbers here!

Upcoming Meetings & Trainings

Addiction Health Services Research Conference, October 13-15, 2016, Seattle, WA. Registration is OPEN! Visit conference website. . .

In the Weeds: Assessing Neurocognitive Brain Imaging and Substance Abuse Measures in Emerging Adults. CTN Webinar Series. July 13, 2016, 1-2p.m. ET. Register now!

Improving Care of Adolescents with Substance Use Disorders: Effective Approaches to Assessing, Treating, and Engaging Teens. Sponsored by the NE Node of the CTN and the New England ATTC. July 20, 2016, at Dartmouth-Hitchcock Medical Center in Lebanon, NH. Read more. . .