CTN Bulletin logo
February 24, 2017   

Primary Outcomes from CTN-0037: STRIDE



The STimulant Reduction Intervention using Dosed Exercise (STRIDE) study was a randomized clinical trial conducted in 9 residential addiction treatment programs across the United States from July 2010 to February 2013.

Of 497 adults referred to the study, 302 met all eligibility criteria, including DSM-IV criteria for stimulant abuse and/or dependence, and were randomized to either a dosed exercise intervention (Exercise) or a health education intervention (Health Education) control, both augmenting treatment as usual and conducted thrice weekly for 12 weeks. The primary outcome of percent stimulant abstinent days during study weeks 4 to 12 was estimated using a novel algorithm adjustment incorporating self-reported Timeline Followback (TLFB) stimulant use and urine drug screens (UDS) data.

Mean percent of abstinent days based on TLFB was 90.8% for Exercise and 91.6% for Health Education participants. Percent of abstinent days using the eliminate contradiction (ELCON) algorithm was 75.6% (SD=27.4%) for Exercise and 77.3% (SD=25.1%) for Health Education.

The primary intent-to-treat analysis, using a mixed model controlling for site and the ELCON algorithm, produced no treatment effect (P=0.60).

However, in post hoc analyses controlling for treatment adherence and baseline stimulant use, Exercise participants had a 4.8% higher abstinence rate (78.7%) compared to Health Education participants (73.9%) (P=0.03, number needed to treat=7.2).

Conclusions: The primary analysis indicted no significant difference between exercise and health education. Adjustment for intervention adherence showed modestly but significantly higher percent of abstinent days in the exercise group, suggesting that exercise may improve outcomes for stimulant users who have better adherence to an exercise dose.

Citation: Trivedi MH, et al. Randomized Controlled Trial Comparing Exercise to Health Education for Stimulant Use Disorder: Results from the CTN-0037 STimulant Reduction Intervention Using Dosed Exercise (STRIDE) Study. Journal of Clinical Psychiatry 2017 (in press).

Find it in the CTN Dissemination Library!

CTN Trial Progress

GraphStudy results for Open Studies as of the February 23 trial Progress Report.

CTN-0050 - Long Term Follow-up to CTN-0027: Enrolled 877 (original N=1,267 START Study participants)

CTN-0051 - X-BOT (Extended Release Naltrexone vs. Buprenorphine for Opioid Treatment). Enrolled 570

CTN-0051-A2 - Detoxification TAU. Enrolled 211

CTN-0056-Ot - Testing and Linkage to HIV Care in China. Enrolled 478

CTN-0064 - Linkage to HCV Care. Enrolled 113

Total Enrolled in all Studies: 24,219


This project is supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute, but the information on this site has not been reviewed by NIDA and does not necessarily reflect the views of the Institute.

· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

The National Drug Abuse Treatment Clinical Trials Network Investigator Toolbox

Have you seen all the new documents added to the CTN Investigator Toolbox (located on the CTN Clinical Trials Report website)?

Don’t miss the informative guides on Protocol Deviations and use of the NIDA Data Share Website, both located under the Implementation and Study Closeout section of the Toolbox: https://ctndsc2.com/system/files/ProtocolDeviations.pdf / https://ctndsc2.com/system/files/DataShare.pdf.

While you’re browsing, take a look at the CTN’s recently published guidelines for Addressing Sex as a Biological Variable in the CTN, located under the Protocol Development section of the Toolbox: https://ctndsc2.com/system/files/AddressingSABV.pdf.

Lastly, don’t forget to check out the Table of Contents for a comprehensive, hyperlinked list of all documents available on the Toolbox: https://ctndsc2.com/system/files/InvestigatorToolbox%20Table%20of%20Contents.pdf.

For questions or comments, or if you have suggestions for items you’d like to see added to the Toolbox, please contact Dee Blumberg at dblumberg@emmes.com or Julia Collins at jcollins@emmes.com.

· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

National Drug & Alcohol Facts Week Sets a Record in Global Reach!

National Drug & Alcohol Facts Week® (NDAFW) set an all-time record this year in the number of domestic and international events held during the week of January 23-29.

NDAFW, launched in 2010 by NIDA, and in partnership with NIAAA since 2016, is an annual health observance week for teens to SHATTTER THE MYTHS® about drug and alcohol use by connecting with health and scientific experts.

This year, more than 2,100 community events were held in all 50 states as well as 15 countries -- the largest international reach ever. In addition, on January 26, NIDA celebrated its tenth anniversary of Drugs & Alcohol Chat Day, a live online chat between teens and NIH scientists. More than 50 high schools participated from 50 states.

The directors from NIDA, NIAAA and NIMH were part of more than 60 scientists who participated this year, answering close to 2500 questions from students across the nation, including young U.S. airmen from Yokota Air Force Base in Tokyo, Japan. Online resources included several new drug-specific toolkits for event holders to use, a SHATTTER THE MYTHS® pledge card, and the popular National Drug IQ Challenge, an interactive quiz accessible on mobile devices for teens to test their knowledge about drugs and alcohol.

Visit http://teens.drugabuse.gov/national-drug-facts-week for more information.

See pictures and find links to additional information and resources. . .

New from the ATTC

Scant Opportunities to Learn about Substance Use in Pre-Service Educational Programs was the ATTC Messenger's featured article for February 2017.

It was based on the ATTC White Paper Preparing Students to Work in Integrated Health Care Systems, prepared by the ATTC Pre-Service Education Workgroup (Eric Goplerud, PhD, Holly Hagle, PhD, Tracy McPherson, PhD). This paper reports on the lack of addiction-related training in medical and nursing schools, or similar programs for other health professionals.

ATTC/NIATx Service Improvement Blog: Recent posts include:

  • Tips for Navigating 508 Compliance
  • PPW Project Echo: Building Capacity to Provide Care for Pregnant and Postpartum Women with Substance Use Disorders
  • What Do Med Students and Prescribers Need to Know about Opioid Use Disorders

Webinar: Surgeon General’s Report: Presentation to SAMHSA Grantees, Wed. March 1, 2017.
Facing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and Health, which launched on November 16, 2016, takes a comprehensive look at the problems and solutions of substance use disorders in the U.S. It covers topics including misuse of alcohol, prescription drugs, and other substances, and brings together the best available science on the adverse health consequences of substance misuse. Join this webinar to learn more about the report and how to take action to address addiction in America.

· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

News from the Northeast Node

On Monday, February 6, 2017 Dr. Lisa Marsch, Director of the Northeast Node and the Dartmouth Center for Technology and Behavioral Health (CTBH), testified at a Congressional briefing of the House Bipartisan Heroin Task Force.

Dr. Marsch was invited to attend the briefing to share preliminary data from the NIDA-funded rapid ethnographic study, "Understanding Opioid Overdoses in New Hampshire."

Through the CTBH, Dr. Marsch and the Northeast Node Administration team have been conducting the qualitative study interviewing opioid users and first responders in New Hampshire to examine why NH residents are overdosing on synthetic opioids at a higher rate than any other state in the nation (please see this CDC website for more information on per capita deaths related to fentanyl overdoses).

Dr. Marsch testified at the Task Force briefing alongside Dr. Nora Volkow, Director of the National Institute on Drug Abuse, Dr. Corey Waller, Legislative Advocacy Committee Chairman of the American Society of Addiction Medicine, and Dr. Josh Rising, Director of Health Programs for the Pew Charitable Trusts. The briefing focused on the science and public health challenges of "synthetic" opioids, with a particular focus on fentanyl and carfentanil.

Dr. Marsch was invited to speak at the briefing by Congresswoman Annie Kuster from the state of New Hampshire (NH-02).

"New Hampshire has had the second-highest rate of opioid overdoses in the country per capita, and actually is number one for fentanyl overdoses per capita in the country, having experienced a doubling of fentanyl-related deaths in the last couple of years and an increase of almost 1600% in fentanyl-related deaths in the last 5 years," Dr. Marsch testified at the hearing.

"Every single one of the 75 users that we interviewed reported having observed at least one, and typically more than one, overdoses," Dr. Marsch said. "One young woman said that in the past 2 months she had seen 20-25 overdoses, including her own mother who died from an overdose, her brother, who overdosed 17 times in a matter of months and is now incarcerated, and her own personal use of fentanyl persists.

"This is a time of considerable need but also a time of unprecedented opportunity for us to expand implementation research and understand the best ways to engage a very broad network of stakeholders and systems in creating novel and effective integrated solutions to tackle this crisis we are experiencing as a nation," said Dr. Marsch.

You can view the recorded briefing here.

The "Understanding Opioid Overdoses in New Hampshire study" report is anticipated for this Spring.

· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

Webinars, Trainings, Other Events

Call for Abstracts for INEBRIA, 2017

The INEBRIA conference in New York City, September 14-15, 2017, is now accepting abstract, workshop, and symposium submissions!

Contact for more information: INEBRIA2017@nyumc.org

Hosted by New York University School of Medicine, Department of Population Health.

CTN Annual Scientific & Steering Committee Meeting

Have you registered for the CTN Annual Scientific and Steering Committee Meeting yet? If not, time to get moving! Registration closes on March 1, which is next Wednesday! Register online here.

Be sure to also make your lodging arrangements at the Bethesda North Marriott -- reservations must be made before February 28 to ensure the special rate.

Details and registration: http://apps.leedmci.com/nida/ctn/meetings/


Addiction Health Services Research Conference 2017

The 2017 AHSR Conference will be in Madison, Wisconsin, October 18-20, 2017.

AHSR 2017 is accepting abstract submissions in areas of research related to the overall conference theme of "Patients, Populations, and Processes: Multidisciplinary Approaches to Addiction Health Services Improvement." Abstracts should be submitted by April 15, 2017.

The final deadline for Early Bird registration is July 1, 2017. Read more. . .

Postdoctoral Traineeship in Drug Abuse Treatment & Services
University of California, San Francisco

The Substance Abuse Research Program at UCSF is currently accepting applications to its two-year postdoctoral research training program. This program, funded by a NIDA T32 grant, aims to produce the next generation of leaders in the field of drug abuse treatment and services research.

Download the program flyer (PDF)

Read more on how to apply here. . .

· · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

journal coversNew from the CTN Dissemination Library

Cigarette Smoking in Pregnant Substance Users: Association with Substance Use and Desire to Quit. Winhusen TM, Lewis DF. Journal of Addictive Diseases 2017;36(1):88-91. Get article. . .

Generalizability of Findings from Randomized Controlled Trials: Application to the National Institute of Drug Abuse Clinical Trials Network. Suskida R, et al. Addiction 2017 (in press). Get article. . .

Volatility and Change in Chronic Pain Severity Predict Outcomes of Treatment for Prescription Opioid Addiction. Worley MJ, et al. Addiction 2017 (in press). Get article. . .

Distinctive Trajectories of Opioid Use Over an Extended Follow-Up of Patients in a Multisite Trial on Buprenorphine + Naloxone and Methadone. Hser Y, et al. Journal of Addiction Medicine 2017;11(1):63-69. Get article. . .

Identifying Substance Misuse in Primary Care: TAPS Tool Compared to the WHO ASSIST. Schwartz RP, et al. Journal of Substance Abuse Treatment 2017 (in press). Get article. . .

Drug Abuse Staff and Clients Smoking Together: A Shared Addiction. Guydish JR, et al. Journal of Substance Abuse Treatment 2017 (in press). Get article. . .

Gender Differences Among Treatment-Seeking Adults with Cannabis Use Disorder: Clinical Profiles of Women and Men Enrolled in the Achieving Cannabis Cessation-Evaluating N-acetylcysteine Treatment (ACCENT) study. Sherman BJ, et al. Am J Addict 2017 (in press). Get article. . .

Causes of Death and Expected Years of Life Lost Among Treated Opioid-Dependent Individuals in the United States and Taiwan. Chang K, et al. International Journal of Drug Policy 2017;45:1-6. Get article. . .


Published by the CTN Dissemination Library of the Pacific Northwest Node
Alcohol & Drug Abuse Institute, University of Washington

This project is supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol & Drug Abuse Institute, but the information on this site has not been reviewed by NIDA and does not necessarily reflect the views of the Institute.

Unsubscribe | Subscribe

Copyright (C) 2016 Alcohol and Drug Abuse Institute. All rights reserved.