American Journal on Addictions 2014;23(1):27-33. [doi: 10.1111/j.1521-0391.2013.12057.x]
Christine S. Meade, PhD (Duke University, SC Node), Lisa A. Bevilacqua (Duke Global Health Institute, SC Node), Elizabeth D. Moore, MSc (Duke University, SC Node), Margaret L. Griffin, PhD (McLean Hospital, NEC Node), John G. Gardin, II, PhD (ADAPT, Inc., WS Node), Jennifer Sharpe Potter, PhD, MPH (University of Texas Health Science Center, TX Node), Mary A. Hatch-Maillette, PhD (Alcohol & Drug Abuse Institute, UW, PN Node), Roger D. Weiss, MD (McLean Hospital, NEC Node).
This study examined in- and post-treatment mediation effects of a 12-session dose of Seeking Safety (SS) -- an integrative cognitive behavioral treatment for comorbid PTSD and SUDs -- on alcohol and cocaine outcomes in comparison to Women's Health Education (WHE) in a seven-site randomized controlled effectiveness trial, CTN protocol 0015, "Women's Treatment for Trauma and Substance Abuse." Women (n=353) enrolled in outpatient substance abuse treatment, who had experienced multiple traumas in childhood and/or adulthood and who had comorbid PTSD, were randomly assigned to receive SS or WHE delivered in open enrollment groups for 12 sessions in 6 weeks (unlike the full 25-topic SS protocol). Data were analyzed under two forms of longitudinal mediation analysis, each accounting for changes over time in group membership and group context, respectively. Women in SS, compared to WHE, showed significantly steeper decreases in PTSD frequency and severity, which in turn showed significant impact in reducing both cocaine and alcohol use. This pattern was strongest for those who completed most of the treatment sessions, which was the majority of patients in the trial; these patterns only emerged during the in-treatment phase.
Conclusions: Use of an integrated approach to PTSD/SUD such as Seeking Safety can be helpful in more rapidly reducing PTSD, which consequently reduces SUD symptoms, particularly for those who attend most of the available treatment sessions. This is one of the first studies to illustrate such effects in treating comorbid PTSD and SUD in the context of a highly impaired population delivered by community-based providers. (Article (Peer-Reviewed), PDF, English, 2013)
Keywords: CTN platform/ancillary study | Condom use | HIV/AIDS | Opioid dependence |
Prescription-type opiates | Risk Behavior Survey (RBS) | Sexual risk behavior | Sexually transmitted diseases | American Journal on Addictions (journal)
Document No: 1017, PMID: 24313238, PMCID: PMC3914665.
Submitted by CTN Dissemination Librarians, 8/5/2013