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Reductions in Cannabis Use are Associated with Improvements in Anxiety, Depression, and Sleep Quality, but Not Quality of Life.

Journal of Substance Abuse Treatment 2017;81:53-58. [doi: 10.1016/j.jsat.2017.07.012]

Yih-Ing Hser, PhD (University of California, Los Angeles), Larissa J. Mooney, MD (University of California, Los Angeles), David Huang, DrPh (University of California, Los Angeles), Yuhui Zhu, MS (University of California, Los Angeles), Rachel L. Tomko, PhD (Medical University of South Carolina, SC Node), Erin McClure, PhD (Medical University of South Carolina, SC Node), Chou Chih-Ping, PhD (University of Southern California), Kevin M. Gray, MD (Medical University of South Carolina, SC Node).

This study examined the longitudinal association between reductions in cannabis use and changes in anxiety, depression, sleep quality, and quality of life. Secondary analyses were conducted based on data from a cannabis use disorder medication trial in 302 adults, NIDA Clinical Trials Network protocol CTN-0053, Achieving Cannabis Cessation: Evaluating N-Acetylcysteine Treatment (ACCENT). Changes in symptoms of anxiety and depression, sleep quality, and quality of life were assessed in relation to changes in cannabis use during the 12-week trial of treatment.

Based on the slope of individual cannabis use trajectory, the sample was classified into two groups (Cannabis Use Reduction, n=152 vs. Cannabis Use Increase, n=150) which was included as a binary covariate in subsequent modeling. Controlling for demographics (age, gender, race/ethnicity), treatment condition, and time-varying tobacco and alcohol use, separate latent growth curve models showed a significant association between the Cannabis Use Reduction group and improvement (i.e., lower values in slope) in anxiety, depression, and sleep quality over the observation period, but not in quality of life.

Conclusions: These results indicate a longitudinal relationship between reductions in cannabis use and improvements in anxiety, depression, and sleep quality. Clinicians treating patients with co-occurring cannabis use and problems with anxiety, depression, or sleep quality should attend to cannabis use reduction as a component of treatment. (Article (Peer-Reviewed), PDF, English, 2017)

Keywords: Anxiety disorders | Co-occurring disorders | CTN platform/ancillary study | Depression | Marijuana | Sleep disorders | Journal of Substance Abuse Treatment (journal)

Document No: 1277.

Submitted by the CTN Dissemination Librarians (8/3/2017).

Chih-Ping, Chou
Gray, Kevin M. mail
Hser, Yih-Ing mail
Huang, David mail
McClure, Erin mail
Mooney, Larissa J. mail
Tomko, Rachel L. mail
Zhu, Yuhui
NIDA-CTN-0053 www

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 8/2017 --
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