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Impact of Behavioral Drug Abuse Treatment on Sexual Risk Behaviors: An Integrative Data Analysis of Eight Trials Conducted Within the National Drug Abuse Treatment Clinical Trials Network.

Prevention Science 2018;19(6):761-771. [doi: 10.1007/s11121-018-0913-6]

Jennifer L. Brown, PhD (University of Cincinnati, OV Node), Michael D. Eriksen, PhD (University of Cincinnati, OV Node), Nicole K. Gause, MA (University of Cincinnati, OV Node), Gene H. Brody, PhD (Emory University), Jessica M. Sales, PhD (Emory University).

The extent to which behavioral drug abuse treatments affect sexual risk behaviors is largely unknown. This study examined the impact of behavioral drug abuse treatments on sexual risk behaviors using an integrative data analysis approach across eight trials conducted within the NIDA Clinical Trials Network (CTN-0004, 0005, 0006, 0007, 0009, 0013, 0015, and 0021). Participants (N=1305) from eight randomized controlled trials who were sexually active at baseline were included in the pooled dataset; 48.7% were female, 64.1% self-identified as a racial/ethnic minority, with M (SD) age of 34.9 (9.6). Longitudinal logistic regression estimated the probability of risky sexual behavior (i.e., inconsistent condom use and/or > 1 sexual partner in past 30 days) post-intervention with an indicator variable (1 for post-intervention), study condition (control, intervention), and their interaction as predictors; the analysis employed random effects for each trial and included relevant control variables. Time-varying differences in effects based on weeks post-intervention were incorporated using interacted linear and quadratic terms with condition status. Approximately 84.2% reported risky sexual behaviors at baseline. The control and intervention conditions were 18.5 and 17.3 percentage points less likely to report risky sexual behavior post-intervention, respectively.

Conclusions: Results suggest decreasing rates of risky sex engagement until 8 weeks (control) or 9 weeks (intervention post-intervention; risky sexual behavior subsequently increased. Behavioral CTN trial participation was associated with decreased sexual risk behaviors in both the intervention and control trial conditions. Given the heterogeneity of treatment approaches employed across the 8 CTN trials, these results point to the effectiveness of behavioral drug abuse treatment to reduce sexual risk behaviors. To bolster further reductions in sexual risk behavior engagement, there is a need to identify HIV risk reduction interventions that can best be integrated within existing resource-limited substance use disorder treatment programs. (Article (Peer-Reviewed), PDF, English, 2018)

Keywords: Behavior therapy | Condom use | CTN platform/ancillary study | HIV/AIDS | Sexual risk behavior | Sexually transmitted diseases | Preventive Science (journal)

Document No: 1314.

Submitted by CTN Dissemination Librarians, 6/11/2018.


Brody, Gene H.
Brown, Jennifer L. mail
Eriksen, Michael D.
Gause, Nicole K.
Sales, Jessica M.
NIDA-CTN-0004 www
NIDA-CTN-0005 www
NIDA-CTN-0006 www
NIDA-CTN-0007 www
NIDA-CTN-0009 www
NIDA-CTN-0013 www
NIDA-CTN-0015 www
NIDA-CTN-0021 www
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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 8/2018 --
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