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Biological Correlates of Self-Reported New and Continued Abstinence in Cannabis Cessation Treatment Clinical Trials.

Drug and Alcohol Dependence 2018;178:270-277. [doi: 10.1016/j.drugalcdep.2018.03.017]

Nathaniel L. Baker, MS, Kevin M. Gray, MD, Brian J. Sherman, PhD Kristen Morella, MPH, Gregory L. Sahlem, MD, Amanda M. Wagner, MA, Aimee L. McRae-Clark, PharmD (all from Medical University of South Carolina, SC Node).

The agreement between self-reported cannabis abstinence with urine cannabinoid concentrations in a clinical trials setting is not well characterized. This study assessed the agreement between various cannabinoid cutoffs and self-reported abstinence across three clinical trials, one including contingency management for abstinence. All three of the trials included both participant self-report and weekly urine samples for cannabis and creatinine concentration measurements. Bootstrapped data were assessed for agreement between self-reported 7+ day abstinence and urine cannabinoid tests using generalized linear mixed effects models for clustered binary outcomes. One study implemented contingency management for cannabis abstinence. Four hundred and seventy-three participants with 3787 valid urine specimens were included. Urine was analyzed for 11-nor-9-carboxy-delta-9-tetrahydrocannabinol and creatinine using immunoassay methods Biological cutoffs of 50, 100, and 200 ng/ml, as well as changes in CN normalized THCCOOH (25%/50% decrease), were assessed for agreement with self-reported abstinence during the three clinical trials.

Results found that agreement between measured THCCOOH and self-reported abstinence increases with increasing cutoff concentrations, while the agreement with self-reported non-abstinence decreases with increasing cutoff concentrations. Combining THCCOOH cutoffs with recent changes in CN-THCCOOH provides a better agreement in those self-reporting abstinence. Participants in the studies that received CM for abstinence had a lower agreement between self-reported abstinence and returned to use than those in studies that did not have a contingency management component.

Conclusions: Using a combination of both concurrent THCCOOH and recent changes in CN-THCCOOH, the agreement between self-reported cannabis abstinence initiation and measure agreemtn is shortened significantly. (Article (Peer-Reviewed), PDF, English, 2018)

Keywords: CTN platform/ancillary study | Data collection | Marijuana | Urinalysis | Drug and Alcohol Dependence (journal)

Document No: 1317, PMID: 29698894, PMCID: PMC5959795 (available 6/2019).

Submitted by Jack Blaine, CCTN, 7/23/2018.

 

AUTHORS SEARCH LINK
Baker, Nathaniel L. mail
Gray, Kevin M. mail
McRae-Clark, Aimee L.
Morella, Kristen
Sahlem, Gregory L.
Sherman, Brian J.
Wagner, Amanda M.
PROTOCOLS
NIDA-CTN-0053 www
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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 7/2018 -- http://ctndisseminationlibrary.org/display/1317.htm
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