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Cost-Effectiveness of Extended-Release Naltrexone versus Buprenorphine-Naloxone to Prevent Opioid Relapse.

Poster presented at the College on Problems of Drug Dependence (CPDD) annual meeting, San Diego, CA, June 9-14, 2018.

Kathryn McCollister, PhD (University of Miami, FNA Node), Xuan Yang (University of Miami, FNA Node), Jared A. Leff (Weill Cornell Medical College, GNY Node), Joshua D. Lee, MD, MSc (New York University, GNY Node), Edward V. Nunes, MD (Columbia University, GNY Node), Patricia Novo, MPA, MPH (NYU School of Medicine, GNY Node), John Rotrosen, MD (NYU School of Medicine), Bruce R. Schackman, PhD (Weill Cornell Medical College, GNY Node), Sean M. Murphy, PhD (Weill Cornell Medicine, GNY Node).

This study describes the approach and results of a comprehensive cost analysis of NIDA Clinical Trials Network protocol CTN-0051, Extended-Relsease Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT), the first head-to-head randomized clinical trial in the U.S. of extended-release injectable naltrexone (XR-NTX) and buprenorphine-naloxone (BUP-NX) for preventing opioid relapse. The objective was to provide rigorous estimates of the costs of training, inpatient detoxification, and medication management visits, highlighting the variation in these costs across sites and settings. Results found that providing XR-NTX and BUP-NX to patients receiving inpatient detoxification generates relatively modest costs to the healthcare provider. The average costs per patient were $5,416 for XR-NTX and $4,148 for BUP-NX. Results of the X:BOT cost analysis study provide current practical information on the types of costs incurred by providers, payers, and patients for XR-NTX and BUP-NX, but continued research is needed to understand the costs of medication-assisted treatment as the system continues to evolve. (Poster, PDF, English, 2018)

Keywords: Buprenorphine/Naloxone | Cost-effectiveness | Naltrexone | Opioid dependence | Pharmacological therapy | College on Problems of Drug Dependence (CPDD) annual meeting, 2018

Document No: 1322.

Submitted by Patricia Novo, GNY Node, 7/30/2018.

Lee, Joshua D. mail
Leff, Jared A. mail
McCollister, Kathryn mail
Murphy, Sean M. mail
Novo, Patricia
Nunes, Edward V.
Rotrosen, John
Schackman, Bruce R.
Yang, Xuan
NIDA-CTN-0051 www

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 7/2018 --
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