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Brief Report: Sex Differences Among Patients with Opioid Use Disorder Entering a Comparative Effectiveness Medication Trial.

American Journal on Addictions 2018;27(6):465-470. [doi: 10.1111/ajad.12784]

Aimee N.C. Campbell, PhD, MSW (Columbia University, GNY Node), Celestina Barbosa-Leiker, PhD (Washington State University, PN Node), Mary A. Hatch-Maillette, PhD (University of Washington, PN Node), Sarah Mennenga, PhD (New York University School of Medicine, GNY Node), Martina Pavlicova, PhD (Trustees of Columbia University, GNY Node), Jennifer Scodes (Columbia University, GNY Node), Tanya Saraiya (Adelphi University), Shannon Gwin Mitchell, PhD (Friends Research Institute, MA Node), John Rotrosen, MD (NYU School of Medicine) Patricia Novo, MPA, MPH (New York University School of Medicine, GNY Node), Edward V. Nunes, MD (Columbia University, GNY Node), Shelly F. Greenfield, MD, MPH (McLean Hospital, NEC Node).

This ancillary investigation of data from NIDA Clinical Trials Network protocol CTN-0051, a randomized, controlled trial comparing extended-release naltrexone to buprenorphine, examined baseline gender differences in individuals with opioid use disorder (OUD) receiving inpatient services. Participants (N=570) provided demographic, substance use, and psychiatric history information.

Women were significantly younger; more likely to identify as bisexual, live with a sexual partner, and be financially dependent on someone else; and less likely to be employed. Women also reported significantly greater psychiatric comorbidity and risk behaviors, and had shorter duration, but similar age of onset, of opioid use.

Conclusions: Findings underscore economic, psychiatric, and infection vulnerability among women with OUD, which may complicate treatment initiatiion, retention, and recovery. Gender-specific interventions focused on these areas of disparity for women with OUD should be considered, including integration of OUD care with treatment for co-occurring psychiatric disorders and trauma, couples-based risk reduction interventions which address relational dynamics, and interventions that address the unique needs of sexual minority women.

(Peer-reviewed article, PDF, English, 2018)

Keywords: Buprenorphine/Naloxone | CTN platform/ancillary study | Gender differences | Naltrexone | Opioid dependence | Pharmacological therapy | Women | American Journal on Addictions (journal)

Document No: 1330, PMID: 30106494, PMCID: PMC6124662 (available 9/1/2019).

Submitted by Mary Hatch-Maillette, PN Node, 8/15/2018.

AUTHORS SEARCH LINK
Barbosa-Leiker, Celestina mail
Campbell, Aimee N.C. mail
Greenfield, Shelly F. mail
Hatch-Maillette, Mary A. mail
Mennenga, Sarah mail
Mitchell, Shannon Gwin mail
Novo, Patricia
Nunes, Edward V.
Pavlicova, Martina
Rotrosen, John
Saraiya, Tanya
Scodes, Jennifer
PROTOCOLS
NIDA-CTN-0051 www


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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 10/2018 -- http://ctndisseminationlibrary.org/display/1330.htm
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