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Frequency and Type of Adverse Events Associated with Treating Women with Trauma in Community Substance Abuse Treatment Programs.

Poster presented at the College on Problems of Drug Dependence (CPDD) annual meeting, Quebec City, Canada, June 16-21, 2007.

Therese K. Killeen, PhD (Medical University of South Carolina, SC Node), Chanda Brown, PhD, MSW (Charleston Center, SC Node), Aimee Campbell, MSSW (Columbia University School of Social Work, LI Node), Huiping Jiang, PhD (New York State Psychiatric Institute, LI Node), Royce Sampson, MSN, APRN, BC (Medical University of South Carolina, SC Node), Edward V. Nunes, MD (Columbia University and New York State Psychiatric Institute, LI Node), Denise A. Hien, PhD (Columbia University School of Social Work, LI Node).

A substantial number of women who enter substance abuse treatment have a history of trauma and meet criteria for Post Traumatic Stress Disorder (PTSD). Fear regarding the extent to which PTSD treatment can evoke negative consequences remains a research question. The NIDA Clinical Trials Network (CTN) recently completed a national multi-site randomized controlled study with 353 women who met criteria for either full or threshold PTSD and a substance use disorder (SUD) (CTN-0015: Women's Treatment for Trauma and Substance Use Disorders). In the study, eligible women who were enrolled in substance abuse treatment received either 12 sessions of Seeking Safety (SS), a PTSD-specific intervention, or 12 sessions of a women's health education intervention (WHE). All women were enrolled in treatment as usual at the community substance abuse programs. Both substance abuse and PTSD outcomes were assessed post intervention at 7 weeks and at 3, 6, and 12 months and participants were monitored on a weekly basis throughout the study intervention for the occurrence of any adverse events (AEs).

Analysis of the results found that 16% of the women reported study-related AEs throughout the study intervention and at the 7 week post-intervention follow-up. There were no significant between-group differences in the number of women who reported AEs (9% for SS, 7% for WHE). The average number of study-related AEs was 1.5 (0.9) for the SS group and 2.0 (1.2) for the WHE group. The most common study-related AEs were worsening of depressive and PTSD symptoms, but differences were not significant between groups. In conclusion, implementing PTSD treatment in substance abuse treatment programs appears to be safe, with minimal impact on intervention-related adverse psychiatric and substance abuse symptoms. (Presentation, PowerPoint Slides, English, 2006)

Keywords: Gender-specific interventions | Post-traumatic stress disorder | Seeking Safety program | Trauma | Women | Women's Health Education program | College on Problems of Drug Dependence (CPDD) annual meeting, 2007

Document No: 207

Submitted by Therese Killeen, 7/2007.

Brown, Chanda search mail
Campbell, Aimee search mail
Hien, Denise A. search mail
Jiang, Huiping search mail
Killeen, Therese K. search mail
Nunes, Edward V. search mail
Sampson, Royce search mail
NIDA-CTN-0015 search www
Greater New York (formerly Long Island and New York) (Lead) search www
Florida Node Alliance search www
Ohio Valley search www
Pacific Northwest search www
Southern Consortium search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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