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Effect of Depression on Smoking Cessation Outcomes.

Poster presented at the College on Problems of Drug Dependence (CPDD) annual meeting, Quebec City, Canada, June 16-21, 2007.

Susan C. Sonne, PharmD (Medical University of South Carolina, SC Node), Edward V. Nuñes, MD (Columbia University and New York Psychiatric Institute, LI Node), Huiping Jiang, PhD (New York Psychiatric Institute, LI Node), W. Gan (Columbia University and New York Psychiatric Institute, LI Node), Clare Tyson, MA (Medical University of South Carolina, SC Node), Malcolm S. Reid, PhD (Greenwich House, Inc., NY Node).

A great deal of literature has been published on the effect of both cigarette smoking and cessation on mood. Less information is available on the effect of mood on smoking cessation outcomes, particularly in a substance abusing population. The NIDA Clinical Trials Network recently completed a randomized, open label trial comparing the use nicotine patches plus group counseling and treatment as usual (TAU) to TAU alone for substance-dependent outpatients interested in quitting smoking (CTN-0009: Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs). As part of that project, researchers evaluated the effect of depression on smoking cessation outcomes. A total of 225 individuals were randomized in a 2:1 ratio to either Smoking Cessation (SC; n=153) or TAU (n=72). Approximately 31.1% of the sample (n=70) had baseline Beck Depression Inventory (BDI) scores greater than or equal to 20, and about half of the sample (n=110) reported a lifetime history of major depression (MDD). Individuals with a history of MDD reported an earlier age of onset for cigarette smoking, an earlier age of regular smoking, as well as a higher baseline Fagerstrom score. Individuals with baseline BDI scores greater than or equal to 20 smoked 26.3 cigarettes/day (vs. 21.3 for the other group) and also started regular smoking at an earlier age (15.0 vs. 16.5). Although there was not a statistically significant effect of lifetime history of major depression on smoking abstinence rates, there was a greater probability for smoking abstinence for those with lower baseline BDI scores. These data suggest that for individuals with substance dependence who are interested in quitting smoking, evaluation and treatment of depressive symptoms may play an important role in improving smoking cessation outcomes. (Poster, PowerPoint slides, English, 2007)

Keywords: Depression | Nicotine replacement therapy | Pharmacological therapy | Smoking | College on Problems of Drug Dependence (CPDD) annual meeting, 2007

Document No: 209

Submitted by Susan Sonne, PharmD, Co-Principal Investigator, 7/2/2007.

Gan, W. search
Jiang, Huiping search mail
Nunes, Edward V. search mail
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