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American Journal on Addictions 2010;19(2):111-8.. [doi: 10.1111/j.1521-0391.2009.00015.x]
Susan C. Sonne,
PharmD (Medical University of South Carolina, SC Node),
Edward V. Nuñes, MD
(Columbia University and New York State Psychiatric Institute,
LI Node), Huiping Jiang, PhD
(New York State Psychiatric Institute, LI Node), Clare
Tyson, MA (Medical University of South Carolina, SC Node),
John Rotrosen, MD (New York University, NY Node), Malcolm
S. Reid, Ph.D. (New York University
School of Medicine, NY Node).
The NIDA Clinical Trials Network's
recently completed protocol CTN-0009 was a randomized, open label trial
comparing treatment as usual (TAU) combined with nicotine patches
plus cognitive behavioral group counseling for smoking cessation
(n=153) to TAU alone (n=72) for patients enrolled in treatment
programs for drug or alcohol dependence who were interested
in quitting smoking. This article reports
on a secondary analysis evaluating the effect of depressive symptomatology
(n=70) or history of depression (n=110) on smoking cessation
outcomes. A significant association was seen between measures
of depression and difficulty quitting cigarettes. Specifically,
there was a greater probability for smoking abstinence for those
with lower baseline BDI-ll scores (Beck Deperession Inventory).
These data suggest that evaluation and treatment of depressive
symptoms may play an important role in improving smoking cessation
outcomes. (Article (Peer-reviewed), PDF, English, 2010)
Keywords: CTN
platform/ancillary study | Community
health services | Depression
| Nicotine
replacement therapy | Pharmacological
therapy | Smoking
| American
Journal on Addictions (journal)
Document No: 383, PMID: 20163382, PMCID: PMC2826720
Submitted by Jack Blaine, NIDA CCTN, 07/06/2009.
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