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OROS-Methylphenidate or Placebo for Adult Smokers with Attention Deficit Hyperactivity Disorder: Racial/Ethnic Differences.

Drug and Alcohol Dependence 2010;110(1-2):156-159. [doi: 10.1016/j.drugalcdep.2010.02.002]

Lirio S. Covey, PhD (Columbia University Medical Center, LI Node), Mei-Chen Hu, PhD (Columbia University Mailman School of Public Health, NY Node), Theresa M. Winhusen, PhD (University of Cincinnati/CinARC, OV Node), Judith Weissman (Weill-Cornel Medical College), Ivan Berlin, MD, PhD (Hôpital Pitié-Salpêtrière, Paris, France), Edward V. Nunes, MD (New York State Psychiatric Institute, LI Node).

The objective of this secondary analysis of data from protocol CTN-0029 ("A Pilot Study of Osmotic-Release Methylphenidate in Initiating and Maintaining Abstinence in Smokers with ADHD") was to explore racial/ethnic difference in OROS-methylphenidate (OMPH) efficacy when added to nicotine patch and counseling for treating nicotine dependence among smokers with attention deficit hyperactivity disorder (ADHD). Participants were adult smokers with ADHD (202 whites and 51 non-whites) randomly assigned to OMPH or placebo in a multi-site, randomized controlled trial. Study outcomes were complete, prolonged, and point-prevalence abstinence at the end of treatment, and weekly ratings of ADHD symptoms, tobacco withdrawal symptoms, and desire to smoke. The rate of four-week complete abstinence (no slips or lapses) was significantly higher with OMPH than placebo among non-whites but not white participants. Patterns of prolonged and point-prevalence abstinence among non-whites were similar but fell short of statistical significance. OMPH reduced ADHD symptoms in race/ethnic groups, and produced greater reductions in desire to smoke and withdrawal symptoms among the non-white than white participants. Change in desire to smoke, but not in withdrawal or ADHD symptoms predicted abstinence. The ability of OMPH to reduce desire to smoke among non-whites appeared to mediate the medication's positive effect on abstinence. This exploratory study is the first to find a positive response to the active medicatino relative to placebo among non-white smokers that is not seen among their white counterparts. Differential efficacy favoring non-whites of a medication for achieving smoking cessation is a potentially important finding that warrants further investigation. OROS-MPH could be an effective treatment for nicotine dependence among a subgroup of smokers. (Article (Peer-Reviewed), PDF, English, 2010)

Keywords: African Americans | Asians | Attention Deficit Hyperactivity Disorder (ADHD) | Concerta | CTN platform/ancillary study | Hispanics and Latinos | Minority groups | Nicotine replacement therapy | Osmotic-Release Methylphenidate (OROS-MPH) | Pharmacological therapy | Smoking | Drug and Alcohol Dependence (journal)

Document No: 425, PMID: 20219292, PMCID: PMC2913299.

Submitted by the CTN Dissemination Librarians, 3/13/2010.

AUTHORS SEARCH LINK
Berlin, Ivan search
Covey, Lirio S. search mail
Hu, Mei-Chen search
Nunes, Edward V. search mail
Weissman, Judith search
Winhusen, Theresa M. search mail
PROTOCOLS
NIDA-CTN-0029 search www
PARTICIPATING NODES
Ohio Valley (Lead) search www
Greater New York (formerly Long Island and New York) search www
New England Consortium (formerly Northern New England) search www
Western States (formerly Oregon/Hawaii) search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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