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Special Supplement to Journal of Substance Abuse Treatment, "A Decade of Research by the National Drug Abuse Treatment Clinical Trials Network."


Using a Latent Variable Approach to Inform Gender and Racial/Ethnic Differences in Cocaine Dependence: A National Drug Abuse Treatment Clinical Trials Network Study.

Journal of Substance Abuse Treatment 2010;38(suppl 1):S70-S79. [doi: 10.1016/j.jsat.2009.12.011]

Li-Tzy Wu, ScD (Duke University Medical Center, Data & Statistics Center (DSC)), Jeng-Jong Pan, PhD (Center for the Clinical Trials Network, NIDA), Dan G. Blazer, MD, PhD (Duke University Medical Center, DSC), Betty Tai, PhD (Center for the Clinical Trials Network, NIDA), Maxine L. Stitzer, PhD (Johns Hopkins University School of Medicine, MA Node), George E. Woody, MD (University of Pennsylvania School of Medicine, DV Node).

This study applies a latent variable approach to examine gender and racial/ethnic differences in cocaine dependence, to determine the presence of differential item functioning (DIF) or item-response bias to diagnostic questions of cocaine dependence, and to explore the effects of DIF on the predictor analysis of cocaine dependence. The analysis sample included 682 cocaine users enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN) (protocols CTN-0006 and CTN-0007, Motivational Incentives for Enhanced Drug Abuse Recovery in Drug Free/Methadone Clinics, respectively). Participants were recruited from 14 community-based substance abuse treatment programs associated with the CTN, including 6 methadone and 8 outpatient non-methadone programs. Factor and multiple indicators-multiple causes (MIMIC) procedures evaluated the latent continuum of cocaine dependence and is correlates. MIMIC analysis showed that men exhibited lower odds of cocaine dependence than women, controlling for the effects of DIF, years of cocaine use, addiction treatment history, comorbid drug dependence diagnoses, and treatment setting. There were no racial/ethnic differences in cocaine dependence; however, DIF by race/ethnicity was noted. Within the context of multiple community-based addiction treatment settings, women were more likely than men to exhibit cocaine dependence. Addiction treatment research needs to further evaluate gender-related differences in drug dependence in treatment entry and to investigate how these differences may affect study participation, retention, and treatment response to better serve this population. (Article (Peer-Reviewed), PDF, English, 2010)

Keywords: Behavior therapy | Cocaine | Contingency Management (CM) | CTN 10-year anniversary | CTN platform/ancillary study | Gender differences | Methadone maintenance | MIEDAR | Motivational incentives | Retention - Treatment | Stimulant abuse | Women | Journal of Substance Abuse Treatment (journal)

Document No: 433, PMID: 20307798, PMCID: PMC2844882.

Submitted by the CTN Dissemination Librarians (3/23/2010).

Blazer, Dan G. search mail
Pan, Jeng-Jong search
Stitzer, Maxine L. search mail
Tai, Betty search mail
Woody, George E. search mail
Wu, Li-Tzy search mail
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