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Special Supplement to Journal of Substance Abuse Treatment, "A Decade of Research by the National Drug Abuse Treatment Clinical Trials Network."

Pain and Continued Opioid Use in Individuals Receiving Buprenorphine-Naloxone for Opioid Detoxification: Secondary Analyes from the Clinical Trials Network.

Journal of Substance Abuse Treatment 2010;38(suppl 1):S80-S86. [doi: 10.1016/j.jsat.2009.12.007]

Jennifer Sharpe Potter, PhD, MPH (McLean Hospital, NNE Node), Amit Chakrabarti, MD (McLean Hospital, NNE Node), Catherine P. Domier, PhD (Integrated Substance Abuse Programs, UCLA, PR Node), Maureen Hillhouse, PhD (Integrated Substance Abuse Programs, UCLA, PR Node), Roger D. Weiss, MD (McLean Hospital, NNE Node), Walter Ling, MD (Integrated Substance Abuse Programs, UCLA, PR Node).

Pain complaints are common among individuals with opioid dependence. However, few studies investigate pain during opioid detoxification or the impact this pain has on continued opioid use. This secondary analysis utilized data from two Clinical Trials Network randomized controlled trials of buprenorphine-naloxone for short-term opioid detoxification (protocols CTN-0001 and CTN-0002) to examine the extent to which pain was associated with continued opioid use during and immediately following a 13-day detoxification protocol. At follow-up, more severe pain was associated with a greater number of self-reported days of opioid use during the prior 30 days (p < .05) but was not associated with urine toxicology results collected at follow-up. These results, although mixed, have potentially important clinical implications for assessing and addressing pain during opioid detoxification. Pain that is experienced during and immediately following medically monitored detoxification may be associated with continued opioid use. These findings lend further support for continued research on pain among patients with opioid dependence, and suggest potentially important clinical implications regarding pain management during the detoxification process. (Article (Peer-Reviewed), PDF, English, 2010)

Keywords: Buprenorphine/Naloxone | CTN 10-year anniversary | CTN platform/ancillary study | Opioid dependence | Opioid detoxification | Pain management | Pharmacological therapy | Suboxone | Journal of Substance Abuse Treatment (journal)

Document No: 434, PMID: 20307799, PMCID: PMC3150507.

Submitted by the CTN Dissemination Librarians, 3/23/2010.

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