Journal of Acquired Immune Deficiency Syndromes 2010;55(1):65-72. [doi: 10.1097/QAI.0b013e3181d916db]
Christina S. Meade, PhD (Duke University Medical Center, DSC), Roger D. Weiss, MD (McLean Hospital, NNE Node), Garrett M. Fitzmaurice, ScD (McLean Hospital, NNE Node), Sabrina A. Poole, MS (University of Pennsylvania School of Medicine, DV Node), Geetha A. Subramaniam, MD (Mountain Manor Treatment Center, MA Node), Ashwin A. Patkar, MD (Duke University Medical Center, DSC), Hilary Smith Connery, MD (McLean Hospital, NNE Node), George E. Woody, MD (University of Pennsylvania School of Medicine, DV Node).
The objective of this study, an ancillary investigation of CTN-0010 ("Buprenorphine/Naloxone-Facilitated Rehabilitation for Opioid Dependent Adolescents/Youth Adults"), was to assess baseline rates of and changes in HIV drug and sexual risk behavior as a function of gender and treatment in opioid-dependent youth. One hundred fifty participants were randomly assigned to extended buprenorphine/naloxone therapy (BUP) for 12 weeks or detoxification for 2 weeks; all received drug counseling for 12 weeks. HIV risk was assessed at baseline and 4-week, 8-week, and 12-week follow-ups. Behavioral change was examined using generalized estimating equations. Baseline rates of past-month HIV risk for females/males were 51%/45% for injection drug use (IDU), 77%/35% for injection risk, 82%/74% for HIV sexual activity, 14%/24% for multiple partners, and 68%/65% for unprotected intercourse. IDU was found to decrease over time, with greater decreases in BUP versus detoxification and females versus males in BUP. Injection risk did not change for persistent injectors. Sexual activity decreased in both genders and conditions, but sexual risk did not. In conclusion, overall, IDU and sexual activity decreased markedly, particularly in patients on buprenorphine/naloxone and in females, but injection and sexual risk behaviors persisted. Extended BUP should be considered as a safe and effective treatment option for opioid-dependent youth, however, it seems that adjunctive risk reduction counseling may be needed to promote greater decreases in injection and sex risk behaviors. (Article (Peer-Reviewed), PDF, English, 2010)
Keywords: Adolescents | Buprenorphine/Naloxone | CTN platform/ancillary study | Gender differences | HIV/AIDS | Opioid dependence | Opioid detoxification | Pharmacological therapy | Sexual risk behavior | Sexually transmitted diseases | Suboxone | Young adults | Journal of Acquired Immune Deficiency Syndromes (journal)
Document No: 442, PMID: 20393347, PMCID: PMC3148945.
Submitted by the CTN Dissemination Librarians, 4/21/2010.