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Predictors of Buprenorphine-Naloxone Dosing in a 12-Week Treatment Trial for Opioid-Dependent Youth: Secondary Analyses from a NIDA Clinical Trials Network Study.

Presented at the NIDA Blending Conference, "Blending Addiction Science and Practice: Evidence-Based Treatment and Prevention in Diverse Populations and Settings," Albuquerque, NM, April 22-23, 2010.

Roger D. Weiss, MD (McLean Hospital, NNE Node), Amit Chakrabarti, MD (McLean Hospital, NNE Node), George E. Woody, MD (University of Pennsylvania School of Medicine, DV Node), Margaret L. Griffin, PhD (McLean Hospital, NNE Node), Geetha A. Subramaniam, MD (Johns Hopkins University, MA Node), Dorian R. Dodd (McLean Hospital, NNE Node).

This secondary analysis of data from protocol CTN-0010 ("Buprenorphine/Naloxone-Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults") examined baseline patient characteristics to predict dosing of buprenorphine/naloxone for patients aged 15-21. Measures examined included sociodemographic characteristics, substance use, and clinical characteristics. The study found that the presence of pain predicts buprenorphine/naloxone dose levels in opioid-dependent youth, and that patients with pain have comparable opioid use outcomes to those without pain, but require higher buprenorphine/naloxone doses. (Poster, PDF, English, 2010)

Keywords: Adolescents | Buprenorphine/Naloxone | CTN platform/ancillary study | Pain management | Suboxone | Opioid detoxification | Young adults | NIDA Blending Conference, 2010

Document No: 462

Submitted by Roger Weiss, MD, NNE Node.

AUTHORS SEARCH LINK
Chakrabarti, Amit search
Dodd, Dorian R. search
Griffin, Margaret L. search
Subramaniam, Geetha A. search mail
Weiss, Roger D. search mail
Woody, George E. search mail

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 5/2010 -- http://ctndisseminationlibrary.org/display/462.htm
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