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Predictors of Study Retention in Addiction Treatment Trials.

Poster presented at the NIDA Blending Conference, "Blending Addiction Science and Practice: Evidence-Based Treatment and Prevention in Diverse Populations and Settings," Albuquerque, NM, April 22-23, 2010.

Jeffrey E. Korte, PhD, Kathryn M. Magruder, PhD, MPH, Therese Killeen, PhD, Susan C. Sonne, PharmD, Royce Sampson, MSN, APRN-BC, Kathleen T. Brady, MD, PhD (all from Medical University of South Carolina, SC Node).

Differential attrition in research studies is a threat to study validity. Attrition during the treatment phase of a study should be conceptualized and studied separately from attrition during follow-up. Unbiased assessment of intervention effectiveness requires good follow-up rates, and roughly equivalent follow-up rates between groups. By focusing on retention during follow-up, we can improve our ability to maximize internal and external validity of study results. This ancillary investigation examined predictors of follow-up completion in the first 15 CTN protocols to have locked datasets in the CTN. The researchers focused on gender and ethnicity as the main predictors of interest and found that clients on methadone were seen to have better retention than other clients, and among clients NOT on methadone, caucasians were most likely to be lost to follow-up, and Hispanic clients least likely. In particular, Hispanic/other women had better retention than any other group. By improving our ability to identify clients at increased risk of loss to follow-up during research studies, we can devise strategies to maximize retention for all participants. Future analyses will take into consideration other client and protocol characteristics to further refine our assessment of factors related to retention during follow-up. (Poster, PowerPoint slides, English, 2010)

Keywords: Community health services | CTN platform/ancillary study | Gender differences | Hispanics and Latinos | Minority groups | Retention - Research | Women | NIDA Blending Conference, 2010

Document No: 464

Submitted by Jeffrey E. Korte, PhD, SC Node, 5/20/2010.

Brady, Kathleen T. search mail
Killeen, Therese search mail
Korte, Jeffrey E. search mail
Magruder, Kathryn M. search mail
Sampson, Royce search mail
Sonne, Susan C. search mail

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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Updated 5/2010 --