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Association of Race and Ethnicity with Withdrawal Symptoms, Attrition, Opioid Use, and Side-Effects During Buprenorphine Therapy.

Journal of Ethnicity in Substance Abuse 2010;9(2):106-114. [doi: 10.1080/15332641003772587]

E. Sherwood Brown, MD, PhD (University of Texas Southwestern Medical Center, TX Node), Carlos F. Tirado, MD (University of Texas Southwestern Medical Center, TX Node), Abu T. Minhajuddin, PhD (University of Texas Southwestern Medical Center, TX Node), Maureen Hillhouse, PhD (Integrated Substance Abuse Programs, UCLA, PR Node), Bryon H. Adinoff, MD (University of Texas Southwestern Medical Center, TX Node), Walter Ling, MD (Integrated Substance Abuse Programs, UCLA, PR Node), Geetha Doraimani (Integrated Substance Abuse Programs, UCLA, PR Node), Christie Thomas, MPH (Friends Research Institute, Inc., PR Node).

Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Drug Abuse Treatment Clinical Trials Network protocol CTN-0003, "Suboxone (Buprenorphine/Naloxone) Taper : A Comparison of Taper Schedules," were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority populations. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups. These findings suggest an overall favorable treatment outcome for all three racial/ethnic groups during buprenorphine administration and suggest race/ethnicity may not play a major role in buprenorphine response and treatment retention. (Article, Peer-Reviewed, PDF, English, 2010)

Keywords: African Americans | Buprenorphine/Naloxone | Community health services | CTN platform/ancillary study | Hispanics and Latinos | Minority groups | Opioid dependence | Pharmacological therapy | Retention - Treatment | Suboxone | Taper schedules | Journal of Ethnicity in Substance Abuse (journal)

Document No: 484, PMID: 20509084, PMCID: PMC3176716.

Submitted by CTN Dissemination Librarians, 6/8/2010.

Adinoff, Bryon H. search mail
Brown, E. Sherwood search mail
Doraimani, Geetha search
Hillhouse, Maureen search mail
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Tirado, Carlos F. search mail
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