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CTN-0030-A-2
Results Article

Alterations in Brain Structure and Functional Connectivity in Prescription Opioid-Dependent Patients.

Brain 2010;133(7):2098-2114. [doi: 10.1093/brain/awq138]

Jaymin Upadhyay, PhD (McLean Hospital, NNE Node), Nasim Maleki, PhD (McLean Hospital, NNE Node), Jennifer Sharpe Potter, PhD, MPH (McLean Hospital, NNE Node), Igor Elman, MD (McLean Hospital, NNE Node), David Rudrauf, PhD (University of Iowa), Jaime Knudsen (McLean Hospital, NNE Node), Diane Wallin (McLean Hospital, NNE Node), Gautam Pendse, MA, MS (McLean Hospital, NNE Node), Leah McDonald (McLean Hospital, NNE Node), Margaret L. Griffin, PhD (McLean Hospital, NNE Node), Julie Anderson (McLean Hospital, NNE Node), Lauren Nutile (McLean Hospital, NNE Node), Perry Renshaw, PhD (The Brain Institute, University of Utah Medical Centre), Roger D. Weiss, MD (McLean Hospital, NNE Node), Lino Becerra, PhD (McLean Hospital, NNE Node), David Borsook, MD, PhD (McLean Hospital, NNE Node).

This is the Results Article for CTN-0030-A-2. A dramatic increase in the use and dependence of prescription opioids has occurred within the last 10 years. The consequences of long-term prescription opioid use and dependence on the brain are largely unknown, and any speculation is inferred from heroin and methadone studies. To look for data directly demonstrating the effects of long-term prescription opioid use on the brain, this study used structural magnetic resonance imaging (sMRI), diffusion tensor imaging, and resting-state functional magnetic resonance imaging (fMRI) in 10 prescription opioid-dependent patients from protocol CTN-0030 and 10 matched healthy individuals. Criteria for patient selection included: (1) no dependence on alcohol or other drugs; (2) no comorbid psychiatric or neurologic disease; and (3) no medical conditions, including pain. Findings suggest that prescription opioid dependence is associated with structural and functional changes in brain regions implicated in the regulation of affect and impulse control, including bilateral volumetric loss in the amygdala and significantly decreased anisotropy in axonal pathways specific to the amygdala, as well as in reward and motivational functions. Longer duration of prescription opioid exposure was associated with greater changes in functional connectivity. These results may have important clinical implications for uncovering the effects of long-term prescription opioid use on brain structure and function. (Article (Peer-Reviewed), PDF, English, 2010)

Keywords: CTN platform/ancillary study | Magnetic resonance imaging (MRI) | Neurological effects | Prescription-type opiates | Brain (journal)

Document No: 489, PMID: 20558415, PMCID: PMC2912691.

Submitted by CTN Dissemination Librarians, 7/13/2010.

AUTHORS SEARCH LINK
Anderson, Julie search
Becerra, Lino search
Borsook, David search mail
Elman, Igor search
Griffin, Margaret L. search
Knudsen, Jaime search
Maleki, Nasim search
McDonald, Leah search
Nutile, Lauren search
Pendse, Gautam search
Potter, Jennifer Sharpe search mail
Renshaw, Perry search
Rudrauf, David search
Upadhyay, Jaymin search
Wallin, Diane search
Weiss, Roger D. search mail
PROTOCOLS
NIDA-CTN-0030-A-2 search www
NODES & CTPs    
New England Consortium (formerly Northern New England) (Lead) search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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