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Craving Intensity and Withdrawal Severity Across Phases of Opioid Detoxification with Buprenorphine.

Poster presented at the College on Problems of Drug Dependence (CPDD) annual meeting, Scottsdale, AZ, June 12-17, 2010

Hanhui Chen, MD, Maureen Hillhouse, PhD, Geetha Doraimani, Albert Hasson, MSW, Walter Ling, MD (all from Integrated Substance Abuse Programs, UCLA, PR Node).

The occurrence of craving and withdrawal symptoms may contribute to relapse to drug use during treatment episodes and recovery efforts. Craving compels drug seeking behavior and withdrawal symptoms are a barrier to sustained abstinence. The current study examines indices of craving intensity and withdrawal symptom severity across time in a detoxification program, and addresses the association between craving and withdrawal symptom severity and drug use. The study analyzed data collected as part of protocol CTN-0003, a 28-day taper trial, using the Visual Analog Scale (VAS) to collect information on self-reported craving intensity and the Clinical Opiate Withdrawal Scale (COWS) to collect clinically observed withdrawal symptoms from 516 opiate-dependent study participants. Results demonstrate that patterns of craving and withdrawal occurred in parallel across the four weeks, with a sharp reduction in both craving and withdrawal symptoms from week 1 to week 2, followed by a slower reduction from week 2 to week 3. Both craving and withdrawal symptoms leveled out from week 3 to week 4. Understanding changes in craving and withdrawal across time in a detoxification program is useful in guiding clinical treatment plans, such as scheduled clinic visits and number of weekly behavioral sessions. (Article, Peer-Reviewed, PDF, English, 2009)

Keywords: Buprenorphine/Naloxone | Craving | Clinical Opiate Withdrawal Scale (COWS) | CTN platform/ancillary study | Opioid dependence | Pharmacological therapy | Suboxone | Taper schedules | Visual Analog Scale for Craving (VAS) | College on Problems of Drug Dependence (CPDD) annual meeting, 2010

Document No: 503

Submitted by Maureen Hillhouse, PhD, PR Node, 6/29/2010.

AUTHORS SEARCH LINK
Chen, Hanhui search
Doraimani, Geetha search
Hasson, Albert search mail
Hillhouse, Maureen search mail
Ling, Walter search mail
PROTOCOLS
NIDA-CTN-0003 search www
PARTICIPATING NODES
Pacific Region (Lead) search www
Greater New York (formerly Long Island and New York) search www
New England Consortium (formerly New England) search www
North Carolina search www
Pacific Northwest search www
Rocky Mountain Regional search www
Western States (formerly Oregon/Hawaii) search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 6/2010 -- http://ctndisseminationlibrary.org/display/503.htm
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