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Predictors of Study Retention in Drug Abuse Treatment Trials.

Poster presented at the College on Problems of Drug Dependence (CPDD) annual meeting, Scottsdale, AZ, June 12-17, 2010.

Jeffrey E. Korte, PhD, Kathryn M. Magruder, PhD, MPH, Susan C. Sonne, PharmD, Royce Sampson, MSN, APRN-BC, Kathleen T. Brady, MD, PhD (all from Medical University of South Carolina, SC Node).

Participant retention is critically important for clinical research studies in the area of addictions. This study, using data from fifteen trials in the National Drug Abuse Treatment Clinical Trials Network, sought to examine predictors of retention in a series of treatment outcome studies. Studies were combined, defining retention through the final follow-up visit, and multivariate logistic regression models were used to assess predictors of study retention, focusing on age, gender, and ethnicity (non-Hispanic White, African American, and Hispanic/Other). Results found no clear pattern, however retention seemed higher in adult pharmacological trials and lower in sexual risk reduction trials. Younger participants were more likely to drop out and, in comparison to African American participants, non-Hispanic Whites were more likely and Hispanic/Others less likely, to drop out. In terms of gender, no significant difference was found between the sexes, though a significant interaction was discovered between ethnicity and gender in relation to study retention. This interaction was largely driven by Hispanic/Other women (not in methadone treatment), who were approximately 40% less likely to be lost to follow-up than their African American counterparts. The results suggest that strategies focused on improving study retention in younger subjects, and in non-Hispanic females, may be particularly important for increasing participant retention and improving the validity of clinical trial data. (Poster, PowerPoint slides, English, 2010)

Keywords: Adolescents | African Americans | CTN platform/ancillary study | Gender differences | Hispanics and Latinos | Minority groups | Retention - Research | College on Problems of Drug Dependence (CPDD) annual meeting, 2010

Document No: 506

Submitted by Jeffrey Korte, PhD, Medical University of South Carolina, SC Node, 7/8/2010.

Brady, Kathleen T. search mail
Korte, Jeffrey E. search mail
Magruder, Kathryn M. search mail
Sampson, Royce search mail
Sonne, Susan C. search mail
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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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Updated 7/2010 --