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From the CTN Special Issue of American Journal of Drug and Alcohol Abuse: Read the other articles here.




Ten Take Home Lessons from the First 10 Years of the CTN and 10 Recommendations for the Future.

American Journal of Drug and Alcohol Abuse 2011;37(5):275-282. [doi: 10.3109/00952990.2011.596978]

Kathleen M. Carroll, PhD (Yale University School of Medicine, NEC Node), Samuel A. Ball, PhD (Yale University School of Medicine, NEC Node), T. Ronald Jackson, MSW (Evergreen Treatment Services, PN Node), Steve Martino, PhD (Yale University School of Medicine, NEC Node), Nancy M. Petry, PhD (University of Connecticut Health Center, NEC Node), Maxine L. Stitzer, PhD (Johns Hopkins University School of Medicine, MA Node), Elizabeth A. Wells, PhD, (Alcohol & Drug Abuse Institute, University of Washington, PN Node), Roger D. Weiss, MD (McLean Hospital, NEC Node).

The first ten years of the National Institute on Drug Abuse’s Clinical Trials Network (CTN) yielded a wealth of data on the effectiveness of a number of behavioral, pharmacologic, and combined approaches in community based settings. This article summarizes some of the methodological contributions and lessons learned from the behavioral trials conducted during its first ten years, including the capacity and enormous potential of this national research infrastructure. The CTN made contributions to the methodology of effectiveness research; new insights from secondary analyses; the extent to which approaches with strong evidence bases, such as contingency management, extend their effectiveness to real world clinical settings; new data on "standard treatment" as actually practiced in community programs; the extent to which retention remains a major issue in the field; important data on the safety of specific behavioral therapies for addiction; and heightened the importance of continued sustained attention to bridging the gap between treatment and research.

Conclusions: Areas of focus for the CTN’s future include defining common outcome measures to be used in treatment outcome studies for illicit drugs; incorporating performance indicators and measures of clinical significance; conducting comparative outcome studies; contributing to the understanding of effective treatments of comorbidity; reaching underserved populations; building implementation science; understanding long-term outcomes of current treatments and sustaining treatment effects; and conducting future trials more efficiently. (Article (Peer-Reviewed), PDF, English, 2011)

Keywords: Adoption of interventions | Behavior therapy | Community health services | Co-occurring disorders | CTN research agenda | Evidence-based treatment | Motivational incentives | Retention | Safety reporting | American Journal of Drug and Alcohol Abuse (journal)

Document No: 679, PMID: 21854269, PMCID: PMC3232679.

Submitted by CTN Dissemination Librarians, 8/23/2011.


Ball, Samuel A. mail
Carroll, Kathleen M. mail
Jackson, T. Ronald mail
Martino, Steve mail
Petry, Nancy M. mail
Stitzer, Maxine L. mail
Weiss, Roger D. mail
Wells, Elizabeth A. mail

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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