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The Potential Impact of Recruitment Method on Sample Characteristics and Treatment Outcomes in a Psychosocial Trial for Women with Co-Occurring Substance Use Disorder and PTSD.

Drug and Alcohol Dependence 2012;120(1-3):225-228. [doi: 10.1016/j.drugalcdep.2011.06.014]

Theresa M. Winhusen, PhD (University of Cincinnati, CinARC, OV Node), Erin L. Winstanley, PhD (University of Cincinnati, CinARC, OV Node), Eugene C. Somoza, MD, PhD (University of Cincinnati, CinARC, OV Node), Gregory S. Brigham, PhD (Maryhaven, Inc., OV Node).

Recruitment method can impact the sample composition of a clinical trial and, thus, the generalizability of the results, but the importance of recruitment method in substance use disorders trials has received little attention. This paper sought to address this research gap by evaluating the association between recruitment method and sample characteristics and treatment outcomes in a substance use disorder trial. In the National Drug Abuse Treatment Clinical Trials Network study, protocol CTN-0015, a multi-site trial evaluating Seeking Safety (SS) relative to Women's Health Education (WHE) for women with co-occurring PTSD and substance use disorders, one site assessed the method by which each participant was recruited. Data from this site (n=106) which recruited participants from newspaper advertising and clinic intakes, were analyzed. Participants recruited through advertising, relative to those from the clinic, had significantly higher levels of baseline drug use and higher rates of DSM-IV-TR criteria for full PTSD. Results suggest that the effectiveness of SS in decreasing PTSD symptoms was greater for participants recruited through advertising relative to those recruited from the clinic. Conversely, the results revealed a significant treatment effect in the clinic-recruited participants, not seen in the advertising-recruited participants, with SS, relative to WHE, participants being more likely to report past week drug use during the follow-up phase. In conclusion, recruitment method may impact sample composition and treatment effects. Replication of this finding would have important implications for substance use disorder efficacy trials which often utilize advertising to recruit participants. (Article (Peer-Reviewed), PDF, English, 2012)

Keywords: Clinician Administered PTSD Scale (CAPS) | Co-occurring disorders | CTN platform/ancillary study | Gender-specific interventions | Post-traumatic stress disorder (PTSD) | Post-Traumatic Stress Disorder Symptom Scale (PSS-SR) | Recruitment | Seeking Safety program | Trauma | Women | Women's Health Education program | Drug and Alcohol Dependence (journal)

Document No: 705, PMID: 21752556, PMCID: PMC3210936.

Submitted by CTN Dissemination Librarians, 7/14/2011.

Brigham, Gregory S. search mail
Somoza, Eugene C. search mail
Winhusen, Theresa M. search mail
Winstanley, Erin L. search mail
NIDA-CTN-0015 search www
Ohio Valley search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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