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From the CTN Special Issue of American Journal of Drug and Alcohol Abuse: Read the other articles here.



Comparative Profiles of Men and Women with Opioid Dependence: Results from a National Multisite Effectiveness Trial.

American Journal of Drug and Alcohol Abuse 2011;37(5):313-323. [doi: 10.3109/00952990.2011.596982]

Sudie E. Back, PhD (Medical University of South Carolina, SC Node), Rebecca Payne, MD (Medical University of South Carolina, SC Node), Amy Herrin Wahlquist, MS (Medical University of South Carolina, SC Node), Rickey E. Carter, PhD (Mayo Clinic), Zachary Stroud, MD (Medical University of South Carolina, SC Node), Louise F. Haynes, MSW (Medical University of South Carolina, SC Node), Maureen Hillhouse, PhD (Integrated Substance Abuse Programs, UCLA, PR Node), Kathleen T. Brady, MD, PhD (Medical University of South Carolina, SC Node), Walter Ling, MD (Integrated Substance Abuse Programs, UCLA, PR Node).

Accumulating evidence indicates important gender differences in substance use disorders. Little is known, however, about gender differences and opioid use disorders. This study aimed to compared demographic characteristics, substance use severity, and other associated areas of functioning (as measured by the Addiction Severity Index-Lite (ASI-Lite)) among opioid-dependent men and women participating in a multisite effectiveness trial. Participants were 892 adults screened for the National Drug Abuse Treatment Clinical Trials Network (CTN) investigation of the effectiveness of two buprenorphine tapering schedules (protocol CTN-0003). The majority of men and women tested positive for oxycodone (68% and 65%, respectively) and morphine (89% each). More women than men tested positive for amphetamines (4% vs. 1%, p < .01), methamphetamine (11% vs. 4%, p < .01), and phencyclidine (8% vs. 4%, p = .02). More men than women tested positive for methadone (11% vs. 6%, p = .05) and marijuana (22% vs. 15%, p = .03). Craving for opioids was significantly higher among women (p < .01). Men evidenced higher alcohol (p < .01) and legal (p = .04) ASI composite scores, whereas women had higher drug (p < .01), employment (p < .01), family (p < .01), medical (p < .01), and psychiatric (p < .01) ASI composite scores. Women endorsed significantly more current and past medical problems.

Conclusions: Important gender differences in the clinical profiles of opioid-dependent individuals were observed with regard to substance use severity, craving, medical conditions, and impairment in associated areas of functioning. The findings enhance understanding of the characteristics of treatment-seeking men and women with opioid dependence, and may be useful in improving identification, prevention, and treatment efforts for this challenging and growing population. (Article (Peer-Reviewed), PDF, English, 2011)

Keywords: Alcohol | Amphetamines | Buprenorphine/Naloxone | CTN platform/ancillary study | Gender differences | Marijuana | Opioid dependence | Prescription-type opiates | Stimulant abuse | Women| American Journal of Drug and Alcohol Abuse (journal)

Document No: 721, PMID: 21854273, PMCID: PMC3164783.

Submitted by CTN Dissemination Librarians, 8/23/2011.

Back, Sudie E. mail
Brady, Kathleen T. mail
Carter, Rickey E.
Haynes, Louise F. mail
Hillhouse, Maureen mail
Ling, Walter mail
Payne, Rebecca
Stroud, Zachary
Wahlquist, Amy Herrin
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