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From the CTN Special Issue of American Journal of Drug and Alcohol Abuse: Read the other articles here.




Gender Research in the National Institute on Drug Abuse National Treatment Clinical Trials Network: A Summary of Findings.

American Journal of Drug and Alcohol Abuse 2011;37(5):301-312. [doi: 10.3109/00952990.2011.596875]

Shelly F. Greenfield, MD, PhD (McLean Hospital, NEC Node), Carmen L. Rosa, MS (Center for the Clinical Trials Network, NIDA), Susan I. Putnins (McLean Hospital, NEC Node), Carla A. Green, PhD MPH (Kaiser Permanente NW, WS Node), Audrey J. Brooks, PhD (University of Arizona, WS Node), Donald A. Calsyn, PhD (Alcohol & Drug Abuse Institute, University of Washington, PN Node), Lisa R. Cohen, PhD (New York State Psychiatric Institute, GNY Node), Sarah J. Erickson, PhD (Center on Alcoholism, Substance Abuse and Addictions (CASAA), SW Node), Susan M. Gordon, PhD (Belmont Center for Comprehensive Treatment, DV Node), Louise F. Haynes, MSW (Lexington/Richland Alcohol and Drug Abuse Council, SC Node), Therese Killeen, PhD, APRN (Medical University of South Carolina, SC Node), Gloria M. Miele, PhD (New York State Psychiatric Institute, GNY Node), Susan Tross, PhD (New York State Psychiatric Institute, GNY Node), Theresa M. Winhusen, PhD (University of Cincinnati/CinARC, OV Node).

The National Institute of Drug Abuse’s National Drug Abuse Treatment Clinical Trials Network (CTN) was established to foster translation of research into practice in substance abuse treatment settings. The multi-site, translational clinical trials of the CTN provide a unique opportunity to examine the outcomes of treatment interventions targeting vulnerable subgroups of women, the comparative effectiveness of gender-specific protocols to reduce risk behaviors, and gender differences in clinical outcomes. This review examined gender-related findings from published CTN clinical trials and related studies from January 2000 to March 2010. CTN studies were selected for inclusion if they focused on treatment outcomes or services for special populations of women with substance use disorders (SUDs) including those with trauma histories, pregnancy, co-occurring eating and other psychiatric disorders, and HIV risk behaviors; or implemented gender-specific protocols. Overall, the CTN has randomized 11,500 participants (41% women) across 200 clinics in 24 randomized controlled trials in community settings, of which 4 have been gender-specific.

Conclusions: These published studies have expanded the evidence base regarding interventions for vulnerable groups of women with SUDs as well as gender-specific interventions to reduce HIV risk behaviors in substance-using men and women. The results also underscore the complexity of accounting for gender in the design of clinical trials and analysis of results. To fully understand the relevance of gender-specific moderators and mediators of outcome, it is essential that future translational studies adopt more sophisticated approaches to understanding and measuring gender-relevant factors and plan sample sizes that are adequate to support more nuanced analytic methods. (Article (Peer-Reviewed), PDF, English, 2011)

Keywords: Co-occurring disorders | CTN platform/ancillary study | Eating disorders | Gender-specific interventions | HIV/AIDS | Pregnant women | Sexual abuse| Sexual risk behavior | Research design | Trauma | American Journal of Drug and Alcohol Abuse (journal)

Document No: 730, PMID: 21854272, PMCID: PMC3160726.

Submitted by CTN Dissemination Librarians, 8/23/2011.


Brooks, Audrey J. mail
Calsyn, Donald A. mail
Cohen, Lisa R. mail
Erickson, Sarah J. mail
Gordon, Susan M. mail
Green, Carla A. mail
Greenfield, Shelly F. mail
Haynes, Louise F. mail
Killeen, Therese mail
Miele, Gloria M. mail
Putnins, Susan I. mail
Rosa, Carmen L. mail
Tross, Susan mail
Winhusen, Theresa M. mail

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