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From the CTN Special Issue of American Journal of Drug and Alcohol Abuse: Read the other articles here.




Smoking Cessation Treatment among Patients in Community-Based Substance Abuse Rehabilitation Programs: Exploring Predictors of Outcome as Clues Toward Treatment Improvement.

American Journal of Drug and Alcohol Abuse 2011;37(5):472-478. [doi: 10.3109/00952990.2011.596981]

Malcolm S. Reid, PhD (New York University School of Medicine, GNY Node), Huiping Jiang, PhD (New York State Psychiatric Institute, GNY Node), Bryan Fallon, PhD (Mt. Sinai Medical Center), Susan C. Sonne, PharmD (Medical University of South Carolina, SC Node), Paul Rinaldi, PhD (St. Luke's Roosevelt Hospital, GNY Node), Eva Turrigiano (New York State Psychiatric Institute, GNY Node), Cynthia L. Arfken, PhD (Wayne State University School of Medicine), James A. Robinson, MEd (Nathan Klein Institute for Psychiatric Research, GNY Node), John Rotrosen, MD (New York University School of Medicine, GNY Node), Edward V. Nunes, MD (New York State Psychiatric Institute, GNY Node).

Predictors of smoking cessation (SC) treatment outcome were explored in a multisite clinical trial of SC treatment at community-based, outpatient, substance abuse rehabilitation programs affiliated with the National Drug Abuse Treatment Clinical Trials Network (protocol CTN-0009). Cigarette smokers from five methadone maintenance programs and two drug and alcohol dependence treatment programs were randomly assigned to SC treatment as an adjunct to substance abuse treatment as usual or to substance abuse treatment as usual. SC treatment consisted of group counseling (weeks 1–8) plus transdermal nicotine patch treatment (21 mg/day, weeks 1–6; 14 mg/day, weeks 7–8). Demographic and clinical predictors of smoking abstinence were evaluated among those patients assigned to the active SC condition (N = 153) using logistic regression. Results found that abstinence during treatment was positively associated with younger age, Hispanic or Caucasian (as opposed to African American) ethnicity/race, employment or student status, fewer cigarettes per day at baseline, lower severity of the primary substance problem at baseline, and higher methadone doses (among the subsample in methadone treatment).

Conclusions: During future efforts to improve smoking cessation treatments among drug- and alcohol-dependent patients, consideration should be given to adequate treatment to reduce the severity of the primary drug or alcohol problem, tailoring treatments for patients with greater severity of smoking and of the primary substance problem, and culturally sensitive interventions. Analysis of predictors of outcome may be a useful tool for treatment development. (Article (Peer-Reviewed), PDF, English, 2011)

Keywords: Community health services | CTN platform/ancillary study | Methadone maintenance | Nicotine replacement therapy | Pharmacological therapy | Smoking | American Journal of Drug and Alcohol Abuse (journal)

Document No: 740, PMID: 21854292, NIHMS No: NIHMS349054.

Submitted by CTN Dissemination Librarians, 8/23/2011.


Arfken, Cynthia L.
Fallon, Bryan
Jiang, Huiping
Nunes, Edward V. mail
Reid, Malcolm S.
Rinaldi, Paul mail
Robinson, James A. mail
Rotrosen, John mail
Sonne, Susan C. mail
Turrigiano, Eva
NIDA-CTN-0009 www
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