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The Appalachian Tri-State Node Experiences with the National Institute on Drug Abuse Clinical Trials Network.

Mind & Brain 2011;2(1):56-66.

Thomas M. Kelly, PhD (Western Psychiatric Institute and Clinic, AT Node), Dennis C. Daley, PhD, LSW (Western Psychiatric Institute and Clinic, AT Node), Mimmie Byrne, PhD (University of Miami Miller School of Medicine, FNA Node), Larry DeMarzo (House of the Crossroads, AT Node), Doris Smith, MA, LPCC, CCDC III-E (Meridian Services, Inc., AT Node), Stephanie Madl, MEd, LPC, CAC (Southwestern Pennsylvania Human Services, AT Node).

The National Institute on Drug Abuse (NIDA)-sponsored Clinical Trial Network (CTN) recently celebrated 10 years of conducting "real world" research into the treatment of addiction. This article reviews the history and results of the most recent CTN studies and describes the experiences of one of the 13 participating research affiliates, the Appalachian Tri-State (ATS) Node. We discuss our "bidirectional" collaboration with multiple community treatment programs (CTPs) on research and dissemination activities and include their experiences as a member of our ATS Node. Results of CTN clinical trials have found unexpectedly that treatment as usual (TAU) is often almost as good as evidence-based interventions such as Motivational Interviewing (MI), possibly due to the difficulty in implementing evidence-based practices most effectively among divergent treatment sites and heterogeneous clinical populations. Some expected findings from the reviewed research are that severity of addiction and comorbidity moderate treatment outcomes and must be accounted for in future CTN-sponsored studies. Notwithstanding these results, much has been learned and recommendations are suggested for changes in CTN research designs that will address methodological limitations and increase treatment effectiveness in future CTN studies. (Article (Peer-Reviewed), PDF, English, 2011)

Keywords: Adoption of interventions | Community health services | CTP participation | Dissemination | National Drug Abuse Treatment Clinical Trials Network | Research participation | Mind & Brain (journal)

Document No: 748, PMID: 22102966, PMCID: PMC3217255.

Submitted by CTN Dissemination Librarians, 9/6/2011.


Byrne, Mimmie mail
Daley, Dennis C. mail
DeMarzo, Larry mail
Kelly, Thomas M. mail
Madl, Stephanie mail
Smith, Doris search mail
Appalachian Tri-State www

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 9/2011 --
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