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Compensation Effects on Clinical Trial Data Collection in Opioid-Dependent Young Adults.

American Journal of Drug and Alcohol Abuse 2012;38(1):81-86. [doi: 10.3109/00952990.2011.600393]

Claire E. Wilcox, MD (University of New Mexico, SW Node), Michael P. Bogenschutz, MD (University of New Mexico, SW Node), Masato Nakazawa (University of New Mexico, SW Node). George E. Woody, MD (University of Pennsylvania School of Medicine, DV Node).

Attrition in studies of substance use disorder treatment is problematic, potentially introducing bias into data analysis. This secondary analysis of data from protocol CTN-0010 ("Buprenorphine/Naloxone-Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults") aimed to determine the effect of participant compensation amounts on rates of missing data and observed rates of drug use. In the study, treatment-seeking opioid-dependent subjects aged 15-21 were randomized to a 2-week detoxification with buprenorphine/naloxone (DETOX) or 12 weeks buprenorphine/naloxone (BUP). Participants were compensated $5 for weekly urine drug screens and self-reported drug use information and $75 for more extensive assignments at weeks 4, 8, and 12. Though BUP assignment decreased the likelihood of missing data, there were significantly less missing data at 4, 8, and 12 weeks than other weeks, and the effect of compensation on the probability of urine screens being positive was more pronounced in DETOX subjects.

Conclusions: These findings suggest that variations in the amount of compensation for completing assignments can differentially affect outcome measurements, depending on treatment group assignment. Adequate financial compensation may minimize bias when treatment condition is associated with differential dropout and may be a cost-effective way to reduce attrition. Moreover, active users may be more likely than non-active users to drop out if compensation is inadequate, especially in control groups or in groups who are not receiving active treatment. (Article (Peer-Reviewed), PDF, English, 2011)

Keywords: Adolescents | Buprenorphine/Naloxone | CTN platform/ancillary study | Missing data | Opioid dependence | Opioid detoxification | Pharmacological therapy | Retention - Treatment | Suboxone | Young adults | American Journal of Drug and Alcohol Abuse (journal)

Document No: 756, PMID: 21936751, PMCID: PMC3745824.

Submitted by the CTN Dissemination Librarians, 9/29/2011.

AUTHORS SEARCH LINK
Bogenschutz, Michael P. search mail
Nakazawa, Masato search
Wilcox, Claire. E. search
Woody, George E. search mail
PROTOCOLS
NIDA-CTN-0010 search www
PARTICIPATING NODES
Delaware Valley (Lead) search www
Mid-Atlantic search www
New England Consortium (formerly Northern New England) search www
North Carolina search www
Southwest search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
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