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Protocol: NIDA-CTN-0027: Starting Treatment with Agonist Replacement Therapies (START).

Presented at the American Public Health Association (APHA) annual meeting, Washington, DC, Oct. 28 - Nov. 2, 2011.

Walter Ling, MD (University of California, Los Angeles, PR Node), Andrew J. Saxon, MD (VA Medical Center, PN Node).

Currently in the United States, pharmacological treatment of opioid addiction most commonly consists of replacement therapy with either methadone or buprenorphine/naloxone (bup/nal). Several clinical trials from the NIDA Clinical Trials Network have demonstrated the effectiveness of bup/nal in a variety of treatment settings and populations. Most recently a multi-site, open label, Phase IV study randomized 1269 participants in federally licensed opioid treatment programs to receive either six months of methadone or six months of bup/nal (CTN-0027, "START"). The primary outcomes of the study focused on parameters of liver function; 731 participants completed the study. Worsening of indices of liver health was rare and did not differ by medication condition. Participants in the bup/nal group had poorer treatment retention than did participants on methadone. Adoption of bup/nal treatment in licensed opioid treatment programs will require additional efforts towards treatment retention. (Presentation, PowerPoint slides, English, 2011)

Keywords: Buprenorphine/Naloxone | Community health services | Liver enzymes | Methadone maintenance | Opioid dependence | Pharmacological therapy | Retention - Research | Suboxone | American Public Health Association (APHA) annual meeting, 2011

Document No: 779.

Submitted by Andrew Saxon, MD, PN Node, 11/21/2011.

AUTHORS SEARCH LINK
Ling, Walter search mail
Saxon, Andrew J. search mail
PROTOCOLS
NIDA-CTN-0027 search www
PARTICIPATING NODES    
Pacific Region (Lead) search www
Western States (Lead) search www
Delaware Valley search www
New England Consortium search www
Pacific Northwest search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 11/2011 -- http://ctndisseminationlibrary.org/display/779.htm
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