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Rationale for Using Exercise in the Treatment of Stimulant Use Disorders.

Journal of Global Drug Policy and Practice 2012;6(1):33p.

Tracy L. Greer, PhD (UT Southwestern Medical Center, TX Node), Kolette M. Ring (UT Southwestern Medical Center, TX Node), Diane Warden, MBA (UT Southwestern Medical Center, TX Node), Bruce D. Grannemann, MA (UT Southwestern Medical Center, TX Node), Timothy S. Church, MD (Pennington Biomedical Research Center, Louisiana), Eugene C. Somoza, MD, PhD (University of Cincinnati/CinARC, OV Node), Steven N. Blair, PEd (University of South Carolina, FNA Node), José Szapocznik, PhD (University of Miami, FNA Node), Mark Stoutenberg, PhD (University of Miami, FNA Node), Chad Rethorst, PhD (UT Southwestern Medical Center, TX Node), N. Robrina Walker, PhD (UT Southwestern Medical Center, TX Node), David W. Morris, PhD (UT Southwestern Medical Center, TX Node), Andrzej S. Kosinski, PhD (Duke Clinical Research Institute, DSC), Tiffany L. Kyle, PhD (Center for Drug-Free Living, Inc., FNA Node), Bess Marcus, PhD (Centers for Behavioral and Preventive Medicine, FNA Node), A. Rebecca Crowell, MEd (Nexus Recovery Center, Inc., TX Node), Neal Oden, PhD (EMMES Corporation, DSC), Edward V. Nunes, MD (New York State Psychiatric Institute, GNY Node), Madhukar H. Trivedi, MD (UT Southwestern Medical Center, TX Node).

Novel approaches to the treatment of stimulant abuse and dependence are needed. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a beneficial treatment for stimulant abuse. In addition, exercise has been associated with improvements in many other health-related areas that may be adversely affected by stimulant use or its treatment, such as sleep disturbance, cognitive function, mood, weight, quality of life, and anhedonia. Neurobiological evidence provides plausible mechanisms by which exercise could positively affect treatment outcomes in stimulant abuse. National Drug Abuse Treatment Clinical Trials Network protocol CTN-0037, Stimulant Reduction Intervention using Dosed Exercise (STRIDE), is a multisite randomized clinical trial that compares exercise to health education as potential treatments for stimulant abuse or dependence. If exercise were to have an impact on acute and longer-term outcomes when added to usual substance abuse treatment, this would be of substantial public health importance. Exercise has limited side effects compared with medications, is not likely to interact with concurrent pharmacotherapy, is lower in cost, can be performed at home, can be continued indefinitely if effective in diverting relapse, and may be useful with vulnerable populations such as pregnant women. Exercise may also improve overall health and functional status, and reduce the cost burden associated with substance use disorders. (Article (Peer-Reviewed), PDF, English, 2012)

Keywords: Community health services | CTN protocol development | Craving | Exercise | Stimulant abuse | Journal of Global Drug Policy and Practice (journal)

Document No: 825, PMID: 25364477, PMCID: PMC4214380.

Submitted by CTN Dissemination Librarians, 6/5/2012.


Blair, Steven N. mail
Church, Timothy S. mail
Crowell, A. Rebecca mail
Grannemann, Bruce D. mail
Greer, Tracy L. mail
Kosinski, Andrzej S. mail
Kyle, Tiffany L. mail
Marcus, Bess mail
Morris, David W. mail
Nunes, Edward V. mail
Oden, Neal mail
Rethorst, Chad mail
Ring, Kolette M. mail
Somoza, Eugene C. mail
Stoutenberg, Mark mail
Szapocznik, José mail
Trivedi, Madhukar H. mail
Walker, N. Robrina mail
Warden, Diane mail
NIDA-CTN-0037 www
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The materials on this site have neither been created nor reviewed by NIDA.
Updated 6/2012 --
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