Buprenorphine/Naloxone versus Clonidine for Inpatient Opiate Detoxification

Walter Ling, MD
Lead Investigator

Integrated Substance Abuse Programs
University of California Los Angeles

For decades, clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, one of the most effective means to achieving that goal, has been unavailable outside the very restrictive confines of narcotic treatment programs.  Bup/Nx shows promise as an effective aid for opiate detoxification; however, little data have been generated for the shorter-term use of Bup/Nx for this indication.  Because the diversity of clinics in the CTN provides an unparalleled opportunity to conduct such a clinical endeavor, the utility of Bup/Nx in short term (13 day) detoxification versus clonidine in an inpatient setting was tested in the CTN.
CTN-0001 Study Protocol


A total of 59 of the 77 (77%) in-patients assigned to the Bup/Nx condition achieved the treatment success criterion compared to 8 of the 36 (22%) assigned to clonidine.  The study supports the benefits of Bup/Nx for opioid detoxification in inpatient treatment programs and illustrated important ways in which clinical research can be conducted in community treatment programs.

Primary Outcomes Article: Ling W, et al. A Multi-Center Randomized Trial of Buprenorphine-Naloxone versus Clonidine for Opioid Detoxification: Findings for the National Institute on Drug Abuse Clinical Trials Network. Addiction 2005;100:1090-1110. [get article]


Publications about CTN-0001

Study data from NIDA Data Share

Blending Team Product: Short Term Opioid Withdrawal Using Buprenorphine
Blending Team Product: Buprenorphine Suite (NCT00032955)

NIDA protocol page

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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Updated 4/2012 --