PROTOCOL NIDA-CTN-0001


Buprenorphine/Naloxone versus Clonidine for Inpatient Opiate Detoxification

Walter Ling, MD
Lead Investigator

Integrated Substance Abuse Programs
University of California Los Angeles
lwalter@ix.netcom.com

For decades, clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, one of the most effective means to achieving that goal, has been unavailable outside the very restrictive confines of narcotic treatment programs.  Bup/Nx shows promise as an effective aid for opiate detoxification; however, little data have been generated for the shorter-term use of Bup/Nx for this indication.  Because the diversity of clinics in the CTN provides an unparalleled opportunity to conduct such a clinical endeavor, the utility of Bup/Nx in short term (13 day) detoxification versus clonidine in an inpatient setting was tested in the CTN.
CTN-0001 Study Protocol

PRIMARY FINDINGS

A total of 59 of the 77 (77%) in-patients assigned to the Bup/Nx condition achieved the treatment success criterion compared to 8 of the 36 (22%) assigned to clonidine.  The study supports the benefits of Bup/Nx for opioid detoxification in inpatient treatment programs and illustrated important ways in which clinical research can be conducted in community treatment programs.

Primary Outcomes Article: Ling W, et al. A Multi-Center Randomized Trial of Buprenorphine-Naloxone versus Clonidine for Opioid Detoxification: Findings for the National Institute on Drug Abuse Clinical Trials Network. Addiction 2005;100:1090-1110. [get article]

RELATED RESOURCES

Publications about CTN-0001

Study data from NIDA Data Share

Blending Team Product: Short Term Opioid Withdrawal Using Buprenorphine
Blending Team Product: Buprenorphine Suite

ClinicalTrials.gov (NCT00032955)

NIDA protocol page


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