National Drug Abuse Treatment 

  PROTOCOL NIDA-CTN-0009


Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs

Malcolm Reid , Ph.D.
Lead Investigator

Department of Psychiatry
New York University School of Medicine
423 East 23rd St., VET-17W
New York, NY 10010
malcolm.reid@med.va.gov

The prevalence of cigarette smoking among substance abusers is high, and substance abusers who smoke have more health problems, higher death rates, and more severe drug and alcohol addiction than those who don't. In the past decade, studies have demonstrated that smoking cessation programs and smoke-free policies can be successful in drug and alcohol rehabilitation clinics. Patients stay in treatment longer, they stop smoking for a time, and they do not use more drugs or alcohol than other patients. This study looks at how feasible it is to incorporate a state-of-the-art smoking cessation treatment program into community substance abuse treatment programs and to see if adding such a program will help people quit smoking and stay off of drugs and alcohol better than substance abuse treatment alone. The treatment for quitting smoking consists of group counseling in combination with the nicotine skin patch (NicoDerm CQ). Cigarette smokers from five methadone-maintenance programs and two drug and alcohol dependence treatment programs were randomly assigned to receive either smoking cessation treatment with the transdermal nicotine patch replacement (SC) as an adjunct to usual care, or treatment-as-usual (TAU).

Primary Findings: Smoking abstinence rates in the SC group were greater during treatment and at the 13- and 26-week follow-up visits, compared to the usual care group. Also, the SC group exhibited greater reductions in cigarettes smoked per day, cigarette craving, nicotine withdrawal, and exhaled carbon monoxide levels, compared to the usual care group. SC did not differ from TAU on abstinence from the primary substance of abuse, rates of retention in substance abuse treatment, and craving for primary substance of abuse. Compliance with SC was moderate at best, and was positively associated with rates of smoking abstinence. Smoking cessation treatment improved smoking abstinence and reduced daily smoking without having an adverse effect on substance abuse rehabilitation when given at the same time as outpatient substance abuse treatment. Substance abuse treatment programs should not be hesitant to implement SC for patients seeking treatment for substance use disorders.

Primary Outcomes Paper: Reid M, et al. Smoking cessation treatment in community-based substance abuse rehabilitation programs. Journal of Substance Abuse Treatment 2008;35(1):68-77. [more. . .]

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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