PROTOCOL NIDA-CTN-0010


Buprenorphine/Naloxone-Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults

George Woody, MD
Lead Investigator
Department of Psychiatry
University of Pennsylvania
woody@tresearch.org

The usual treatment for opioid-addicted youth is detoxification and counseling.  Some treatment providers are reluctant to use opioid agonist medications in this population, especially for long-term opioid maintenance.  This study compared Bup/Nx treatment for 9 weeks and taper for 3 weeks to treatment as usual (Bup/Nx detox for 2 weeks).  Both arms received counseling for 12 weeks.
CTN-0010 Study Protocol

PRIMARY FINDINGS

Results of the study showed that continuing Bup/Nx for 12 weeks vs. 2 weeks improved outcomes.  During weeks 1 through 12, patients in the 12-week Bup/Nx group reported less opioid use (P<.001), better retention (70% vs. 21%; p<.0001), less injecting (P=.01), and less use of cocaine (p<.001) and marijuana (p<.001).  Continuing treatment with Bup/Nx for 12 weeks appears to be safe in opioid addicted adolescents and young adults.

Primary Outcomes Article: Woody G, et al. Extended vs. short-term buprenorphine/naloxone for treatment of opioid-addicted youth: A randomized trial. Journal of the American Medical Association 2008;300(17):2003-2011. [get article]

RELATED STUDIES
RELATED RESOURCES

Publications about CTN-0010

Study data from NIDA Data Share

Blending Team Product: Buprenorphine Treatment for Young Adults
Blending Team Product: Buprenorphine Suite

ClinicalTrials.gov (NCT00078130)

NIDA protocol page


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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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Updated 4/2012 -- http://ctndisseminationlibrary.org/protocols/ctn0010.htm
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