PROTOCOL NIDA-CTN-0010-A-2


Comorbid Conditions in Adolescents with Opioid Versus Alcohol/Marijuana Use Disorders

Geetha Subramaniam, MD
Lead Investigator
Mountain Manor Treatment Center
Johns Hopkins University
gsubram@jhmi.edu

This ancillary study is related to CTN-0010, "Buprenorphine/Naloxone-Facilitated Rehabilitation for Heroin Addicted Adolescents/Young Adults."

The purpose of this study was to determine if adolescents with opioid use disorder (OUD) have more co-morbidity than adolescents with marijuana and/or alcohol use disorders.  In the study, we assessed substance use disorder diagnoses, psychiatric diagnoses, HIV-risk behaviors, and illegal acts.  94 adolescents (ages 14-18 years) with a current OUD and 74 adolescents with a current non-OUD cannabis/alcohol use disorders were recruited from admissions, predominantly residential, to Mountain Manor, a substance abuse treatment program in Baltimore, Maryland.  Participants were assessed cross-sectionally using standardized interviews and self-report to determine group differences on demographic, substance use, psychiatric and HIV-risk behaviors.

PRIMARY FINDINGS

The study confirmed that adolescents with opioid-use disorder evidenced greater impairment in academic, more substance use, more depressive symptoms, and higher IDU-related HIV-risk than adolescents with marijuana and/or alcohol use disorders.

Results Article: Subramaniam G, et al. Clinical characteristics of treatment-seeking adolescents with opioid versus cannabis/alcohol use disorders. Drug and Alcohol Dependence 2009;99:141-149. [get article]

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