PROTOCOL NIDA-CTN-0028


Osmotic-Release Methylphenidate for ADHD in Adolescents with Substance Use Disorders

Paula Riggs, MD
Co-Lead Investigator
University of Colorado at Denver
Health Sciences Center
paula.riggs@uchsc.edu

Theresa Winhusen, PhD
Co-Lead Investigator
University of Cincinnati/CinARC
winhusen@mdru.uc.edu

The primary objectives of this study were to evaluate the efficacy of OROS-MPH (Concerta), relative to placebo, in treating ADHD and decreasing substance use in adolescents with ADHD and a substance use disorder.  The study involved 303 participants, recruited from 11 community treatment sites.
CTN-0028 Study Protocol

PRIMARY FINDINGS

OROS-MPH did not show greater efficacy than placebo for ADHD or on reduction in substance use in adolescents concurrently receiving individual CBT for co-occurring SUD. However, OROS-MPH was relatively well tolerated and was associated with modestly greater clinical improvement on some secondary ADHD and substance outcome measures.

Primary Outcomes Article: Riggs PD, et al. Randomized Controlled Trial of Osmotic-Release Methylphenidate with CBT in Adolescents with ADHD and Substance Use Disorders. Journal of the American Academy of Child and Adolescent Psychiatry 2011 (in press). [get article]

RELATED STUDIES
RELATED RESOURCES

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Publications about CTN-0028

Study data from NIDA Data Share

ClinicalTrials.gov (NCT00264797)

NIDA protocol page


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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 8/2011 -- http://ctndisseminationlibrary.org/protocols/ctn0028.htm
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