Osmotic-Release Methylphenidate for ADHD in Adolescents with Substance Use Disorders

Paula Riggs, MD
Co-Lead Investigator
University of Colorado at Denver
Health Sciences Center

Theresa Winhusen, PhD
Co-Lead Investigator
University of Cincinnati/CinARC

The primary objectives of this study were to evaluate the efficacy of OROS-MPH (Concerta), relative to placebo, in treating ADHD and decreasing substance use in adolescents with ADHD and a substance use disorder.  The study involved 303 participants, recruited from 11 community treatment sites.
CTN-0028 Study Protocol


OROS-MPH did not show greater efficacy than placebo for ADHD or on reduction in substance use in adolescents concurrently receiving individual CBT for co-occurring SUD. However, OROS-MPH was relatively well tolerated and was associated with modestly greater clinical improvement on some secondary ADHD and substance outcome measures.

Primary Outcomes Article: Riggs PD, et al. Randomized Controlled Trial of Osmotic-Release Methylphenidate with CBT in Adolescents with ADHD and Substance Use Disorders. Journal of the American Academy of Child and Adolescent Psychiatry 2011 (in press). [get article]



Publications about CTN-0028

Study data from NIDA Data Share (NCT00264797)

NIDA protocol page

Ohio Valley (Lead) search www
Crittenton search
Synergy Treatment Center search
Appalachian Tri-State search www
Addiction Medicine Services search
Delaware Valley search www
Rehab After Work search
Florida Node Alliance search www
Gateway Community Services, Inc. search
Operation PAR, Inc. search
Greater New York search www
(formerly Long Island) search www
St. Luke's Roosevelt Hospital Center search
Mid-Atlantic search www
Mountain Manor Treatment Programs search
New England Consortium search www
(formerly Northern New England) search www
Stanley Street Treatment and Resources (SSTAR) of Massachusetts search
Stanley Street Treatment and Resources (SSTAR) of Rhode Island search
Southern Consortium search www
Lexington-Richland Alcohol and Drug Abuse Council search
Texas search www
Mental Health Mental Retardation of Tarrant County search

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 8/2011 --