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Adult ADHD is a common and impairing neuro-psychiatric disorder, affecting approximating seven to eight millions adults in the United States. Substance use disorders, including cigarette smoking and nicotine dependence, are some of the more common co-morbid disorders with adult ADHD. Studies have found that adults with ADHD are twice as likely to smoke cigarettes and be dependent on nicotine than adults without ADHD.
The primary objective of this study is to evaluate whether OROS MPH
(Concerta), relative to placebo, increases the effectiveness of standard
smoking treatment (i.e., nicotine patch and individual smoking cessation
counseling) in obtaining prolonged abstinence for smokers with ADHD.
The study will involve an estimated 252 participants, recruited from
approximately 6 sites.
Primary Findings: Though OROS-MPH evidenced a greater reduction in ADHD symptoms and cigarettes per day during the post-quit phase, treatment for ADHD did not improve smoking cessation success to a statistically significant degree. OROS-MPH, relative to placebo, effectively treated ADHD and was safe and generally well-tolerated in the sample of healthy adults.
Source: Winhusen TM, et al. Impact of Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment on Smoking Cessation Intervention in ADHD Smokers: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Clinical Psychiatry 2010 (in press). [get article] |
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