PROTOCOL NIDA-CTN-0030-A-3


Protocol Amendment to Examine Long-Term Outcomes

Jennifer Sharpe Potter, Ph.D., M.P.H.
Roger Weiss, M.D.

Lead Investigators
Harvard Medical School, McLean Hospital
jennifer_potter@hms.harvard.edu
rweiss@mclean.harvard.edu

This ancillary study is related to CTN-0030, "Prescription Opioid Addiction Treatment Study (POATS)."

The study objectives are to examine long-term outcomes for individuals with opioid analgesic (OA) dependence who participated in CTN-0030.  Specifically, the study will describe the substance use trajectories of randomized participants and identify factors associated with long-term recovery from OA dependence for future research.  This exploratory, naturalistic study is intended to help generate hypotheses and guidance for further treatment research on opioid analgesic dependence.

CTN-0030-A-3 Study Protocol

PRIMARY FINDINGS

Long-term outcomes for those dependent on prescription opioids demonstrated clear improvement from baseline. These results are consistent with research on heroin dependence in supporting the value of opioid agonist therapy for prescription opioid dependence; however, half of the follow-up participants reported good outcomes without agonist therapy as well. Additionally, a small subset exhibited a worsening course, by initiating heroin use and/or injection opioid use. These data underscore the importance of longer-term follow-up in understanding the course of this increasingly prevalent substance use disorder.

Results Article: Weiss RD, Potter JS, Griffin ML, et al. Long-Term Outcomes from the National Drug Abuse Treatment Clinical Trials Network Prescription Opioid Addiction Treatment Study. Drug and Alcohol Dependence 2015 (in press). [get article]

RELATED STUDIES
RELATED RESOURCES

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Publications about CTN-0030-A-3

Study data from NIDA Data Share


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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 3/2015 -- http://ctndisseminationlibrary.org/protocols/ctn0030a3.htm
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