An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers
Theresa Winhusen, Ph.D. Eugene Somoza, M.D. Lead Investigators University of Cincinnati/CinARC 3210 Jefferson Ave. Cincinnati, OH 45220 winhusen@mdru.uc.edu somoza@uc.edu

This CTN-funded ancillary study is related to CTN-0031, "Stimulant Abusers Group to Engage in 12-Step (STAGE-12)."

The primary objective of this study is to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with methamphetamine use disorders. Secondary objectives include evaluating whether: 1) performance on various neurocognitive tests, including the Stroop, Rey Auditory-Verbal Learning Test (RAVLT), Iowa Gambling Task (GT), Wisconsin Card Sorting Task (WCST), and the Barratt Impulsiveness Scale version 11 (BIS-11) is predictive of treatment attrition and stimulant use outcomes in meth/cocaine abusers; 2) neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in meth/cocaine abusers; 3) oxidative damage, as assessed by two plasma measures, is predictive of treatment attrition and substance use outcomes in meth/cocaine abusers; and 4) oxidative damage in meth/cocaine abusers is significantly greater than that of a normal comparison group.

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