An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers

Theresa Winhusen, Ph.D.
Eugene Somoza, M.D.
Lead Investigators
University of Cincinnati/CinARC

This CTN-funded ancillary study is related to CTN-0031, "Stimulant Abusers Group to Engage in 12-Step (STAGE-12)."

The primary objective of this study is to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with METH use disorders.  Secondary objectives include evaluating whether: 1.) performance on various neurocognitive tests, including the Stroop, Rey Auditory-Verbal Learning Test (RAVLT), Iowa Gambling Task (GT), Wisconsin Card Sorting Task (WCST), and the Barratt Impulsiveness Scale version -11 (BIS-11) is predictive of treatment attrition and stimulant use outcomes in METH/cocaine abusers; 2.)  neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in METH/cocaine abusers; 3.)  oxidative damage, as assessed by two plasma measures, is predictive of treatment attrition and substance use outcomes in METH/cocaine abusers, and 4.)  oxidative damage in METH/cocaine abusers is significantly greater than that of a normal comparison group.

CTN-0031-A-1 Study Protocol


Methamphetamine-dependent and cocaine-dependent patients may have different impulsivity profiles but the BIS-11 may be useful in identifying both methamphetamine-dependent and cocaine-dependent patients who are at risk for treatment non-completion.

Results Article: Winhusen et al. Impulsivity is Associated with Treatment Non-Completion in Cocaine- and Methamphetamine-Dependent Patients but Differs in Nature as a Function of Stimulant-Dependence Diagnosis. Journal of Substance Abuse Treatment 2013;44(5):541-547. [get article]



Publications about CTN-0031-A-1

Study data from NIDA Data Share

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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Updated 11/2013 --