PROTOCOL NIDA-CTN-0031-A-1


An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers

Theresa Winhusen, Ph.D.
Eugene Somoza, M.D.
Lead Investigators
University of Cincinnati/CinARC
winhusen@mdru.uc.edu
somoza@uc.edu

This CTN-funded ancillary study is related to CTN-0031, "Stimulant Abusers Group to Engage in 12-Step (STAGE-12)."

The primary objective of this study is to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with METH use disorders.  Secondary objectives include evaluating whether: 1.) performance on various neurocognitive tests, including the Stroop, Rey Auditory-Verbal Learning Test (RAVLT), Iowa Gambling Task (GT), Wisconsin Card Sorting Task (WCST), and the Barratt Impulsiveness Scale version -11 (BIS-11) is predictive of treatment attrition and stimulant use outcomes in METH/cocaine abusers; 2.)  neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in METH/cocaine abusers; 3.)  oxidative damage, as assessed by two plasma measures, is predictive of treatment attrition and substance use outcomes in METH/cocaine abusers, and 4.)  oxidative damage in METH/cocaine abusers is significantly greater than that of a normal comparison group.

CTN-0031-A-1 Study Protocol

PRIMARY FINDINGS

Methamphetamine-dependent and cocaine-dependent patients may have different impulsivity profiles but the BIS-11 may be useful in identifying both methamphetamine-dependent and cocaine-dependent patients who are at risk for treatment non-completion.

Results Article: Winhusen et al. Impulsivity is Associated with Treatment Non-Completion in Cocaine- and Methamphetamine-Dependent Patients but Differs in Nature as a Function of Stimulant-Dependence Diagnosis. Journal of Substance Abuse Treatment 2013;44(5):541-547. [get article]

RELATED STUDIES
RELATED RESOURCES

snowflake

Publications about CTN-0031-A-1

Study data from NIDA Data Share


NODES & CTPs SEARCH LINK
Ohio Valley (Lead) search www
Maryhaven search www
Pacific Northwest search www
Recovery Centers of King County search www
Western States search
(formerly Oregon/Hawaii) search www
ChangePoint, Inc. search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 11/2013 -- http://ctndisseminationlibrary.org/protocols/ctn0031a1.htm
info@ctndisseminationlibrary.org