Project HOPE: Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users

Lisa R. Metsch, PhD
Lead Investigator
Associate Professor, Dept. of Epidemiology and Public Health
University of Miami Miller School of Medicine

Project HOPE will evaluate the effectiveness of a brief intervention delivered to HIV-infected drug users recruited from the hospital setting in achieving viral suppression.  The trial comprises:  1) an active patient navigator component:  a strengths-based case management approach that includes motivation, physical escort to treatment, and face-to-face booster sessions; and 2) a passive incentives/contingency management component to further motivate and reinforce completion of target behaviors.  The primary goal of the study is HIV viral suppression.  In addition, the study will also determine linkage and retention in HIV primary care, linkage and retention in drug abuse treatment, and reduction in numbers of hospitalizations.


Among hospitalized patients with HIV infection and substance use, patient navigation with or without financial incentives did not have a beneficial effect on HIV viral suppression relative to nonsuppression or death at 12 months vs. treatment as usual. These findings do not support these interventions in this setting and indicate that other approaches are needed to improve HIV outcomes in this vulnerable population.

Primary Outcomes Article: Metsch LR, et al. Effect of Patient Navigation With or Without Financial Incentives on Viral Suppression Among Hospitalized Patients with HIV Infection and Substance Use: A Randomized Trial. JAMA 2016;316(2):156-170. [get article]



Publications about CTN-0049 (NCT01612169)

NIDA protocol page

Florida Node Alliance search www
Grady Memorial Hospital search www
Jackson Memorial Hospital search www
Appalachian Tri-State search www
UPMC Presbyterian search www
Delaware Valley search www
Hahnemann University Hospital search www
Mid-Atlantic search www
Johns Hopkins University search www
New England Consortium search www
Boston Medical Center search www
Ohio Valley search www
Rush University Medical Center search www
John H. Stroger, Jr. Hospital of Cook County search www
Pacific Region search www
Harbor-UCLA Medical Center search www
Southern Consortium search www
University Hospital at University of Alabama search www
Texas search www
Parkland Health and Hospital System search www

Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
The materials on this site have neither been created nor reviewed by NIDA.
Updated 3/2014 --