PROTOCOL NIDA-CTN-0051-A-1


Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT) Genetics Study

Mary Jeanne Kreek, MD
Lead Investigator

Rockefeller University, Kreek Lab
kreek@rockefeller.edu

This ancillary study is related to CTN-0051, "Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT)."

This study will examine functional variants in three genes (OPRM1, OPRK1, and PDYN) known to affect the dynamic response to opioid receptor ligands. These variants will be evaluated for their contribution to treatment retention, abstinence, and depression in the CTN-0051 trial. Their effects will be compared between the two alternative treatments: extended-release injectable naltrexone (XR-NTX) and buprenorphine-naloxone (BUP-NX). Pharmacogenomics application of study results obtained may allow individual tailoring of these medications. In addition, knowledge pertaining to other aspects of pathophysiology of the receptors systems targeted by XR-NTX or BUP-NX may be gained.

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Publications about CTN-0051-A-1


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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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Updated 11/2016 -- http://ctndisseminationlibrary.org/protocols/ctn0051a1.htm
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