PROTOCOL NIDA-CTN-0063-S


Gender Differences in the Interrelationships Between Sexual Abuse, Risky Sexual Behavior, and Anxiety/Depression in Treatment Efficacy and Drug Use Over Time Among Individuals with Substance Use Disorders

Jeffrey Korte, PhD
Lead Investigator

Division of Biostatistics, Bioinformatics, and Epidemiology
Medical University of South Carolina
korte@musc.edu

Investigators will analyze opiate and stimulant users across 3 different treatment modalities from 7 CTN trials focusing on gender differences on the relationship between sexual and physical abuse, anxiety, and depression symptoms; as well as the impact of these factors on SUD treatment efficacy, and HIV risk behaviors.  Investigators will conduct baseline cross-sectional and longitudinal analyses focused on gender differences in history of sexual and physical abuse as they relate to baseline anxiety and depression symptoms, as well as measures of HIV risk behaviors, addiction severity and treatment outcomes; and gender differences in anxiety and depression symptoms as they relate to HIV risk behaviors, addiction severity and treatment outcomes.

PRIMARY FINDINGS

A discussion of gender differences in history of sexual and physical abuse in relation to addiction severity analysis was presented at the 2015 College on Problems of Drug Dependence. Investigators reported while abuse history was associated with higher ASI severity in many domains, only the legal composite subscale demonstrated a stronger association for women. Examination of specific arrests and charges revealed gender differences in abuse-arrest associations including: men with physical abuse are more likely to be charged with assault, disorderly conduct, and driving violations; women with sexual or physical abuse are more likely to report driving violations and DWI; and prostitution was associated with history of sexual abuse in men only.

RELATED RESOURCES
RELATED RESOURCES

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Publications about CTN-0063-S

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Supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute.
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