Initiating Extended-Release Buprenorphine for Opioid Use Disorder in Rural Emergency Department Settings

Ryan McCormack, MD
Co-Lead Investigator

New York University School of Medicine

John Rotrosen, MD
Co-Lead Investigator

New York University School of Medicine

The opioid epidemic has reached a critical state, drawing widespread attention and support to address this public health crisis.  For many reasons, the Emergency Department (ED) is a critical venue to initiate opioid use disorder (OUD) interventions.  ED patients have a disproportionately high prevalence of substance use disorders, are at an elevated risk of overdose, and many do not access healthcare elsewhere. Despite this, OUD interventions are rarely initiated in EDs.  This study seeks to quickly introduce BUP into three EDs to initiate treatment for a broad range of OUD patients presenting with opioid overdoses or in opioid withdrawal, others with OUD-related complications, others seeking OUD treatment, as well as patients presenting for reasons unrelated to OUD, and for all of whom an ED visit may be a unique opportunity to initiate treatment.  The study proposes two components: 1) An open-label non-randomized trial comparing a cohort of patients willing to accept ED-initiated BUP and referral for ongoing MAT to a cohort of patients not willing to accept ED-initiated BUP who will be offered treatment-as-usual (TAU) and who agree to be followed and 2) A qualitative, descriptive study including formative evaluation using mixed methods to learn what is needed to implement ED-initiated BUP and to describe implementation across both study phases. 



Publications about CTN-0079

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Updated 6/2017 --