Happy New Year and Welcome to 2017! |
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CTN Trial Progress
 Study results for Open Studies as of the January 24 trial Progress Report.
CTN-0050 - Long Term Follow-up to CTN-0027: Enrolled 877 (original N=1,267 START Study participants)
CTN-0051 - X-BOT (Extended Release Naltrexone vs. Buprenorphine for Opioid Treatment). Enrolled 570
CTN-0051-A2 - Detoxification TAU. Enrolled 211
CTN-0056-Ot - Testing and Linkage to HIV Care in China. Enrolled 478
CTN-0064 - Linkage to HCV Care. Enrolled 113
Total Enrolled in all Studies: 24,219
Update from the CTN Publications Committee
Summary of Publications Committee activity as of 1/3/2017:
Total papers Submitted and Reviewed: 423
Papers under PC review: 4
Published or accepted for publication: 366 (86.5%)
Under review: 37 (8.8%)
Not Published: 17 (4%)
Not approved by PC: 3 (0.7%)
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The National Drug Abuse Treatment Clinical Trials Network Investigator Toolbox
 Have you seen all the new documents added to the CTN Investigator Toolbox (located on the CTN Clinical Trials Report website)?
Don’t miss the updated Data and Safety Monitoring Board (DSMB) Overview under the Protocol Development section of the Toolbox. This document now includes details on how to prepare supplemental documents for DSMB review, including the Leadership Plan, Recruitment and Retention Plan, and Single IRB Plan.
Interested in expanding your regulatory knowledge? Check out the new Federalwide Assurance (FWA) document, located under the Pre-Implementation section of the Toolbox. This document provides insight on what Federalwide Assurance is, why it’s necessary, and how it applies to your site.
Wondering about how to ensure adequate protections when participants become prisoners during a study? Review the new document on OHRP Prisoner Certification, located under the Pre-Implementation section of the Toolbox. This easy-to-follow document breaks down all of the steps necessary to obtain prisoner certification from the Office for Human Research Protections (OHRP) to allow for follow up with any study participants who may become defined as prisoners following enrollment in a study.
Curious about what else you can find in the Toolbox? Check out the newly-added Table of Contents, available on the Investigator Toolbox main page.
For questions or comments, or if you have suggestions for items you’d like to see added to the Toolbox, please contact Dee Blumberg at dblumberg@emmes.com or Julia Collins at jcollins@emmes.com.
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News from the Nodes
Northeast Node
 The Phase 2 Fentanyl Hot Spot study, "Understanding Opioid Overdoses in New Hampshire," was recently featured in the Union Leader, New Hampshire's premiere source of local news.
This study is supported by the NIDA-funded National Drug Early Warning System (NDEWS) and leverages the infrastructure and partnerships of the Northeast Node of the CTN.
The article, Research: NH tops in fentanyl deaths, was published on January 8, 2017, and describes the study's background, aims, and methods to increase understanding of New Hampshire's alarming rate of fentanyl-related overdose deaths.
This rapid epidemiological study aims to recruit 75 recent opioid consumers in New Hampshire, 18 first responders (police, fire, emergency medical services), and 18 emergency department staff from the six counties in the state that have seen the highest rates of overdoses.
To date, the study team has completed semi-structured qualitative interviews with 61 consumers and 31 responders/emergency staff. Recruitment is expected to wrap in early February. A final report for Phase 2 is anticipated for mid-March.
Read the report for Phase 1 of this study here.
The Northeast Node is pleased to participate in efforts to better understand New Hampshire's fentanyl problem, and to give a voice to the consumers and responders on the front lines of this crisis.
Learn more about both fascinating phases of this study here. . .
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New England Consortium: 2016 in Review
 The New England Consortium Node continued participation in the NIDA CTN-0051 study, "Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT)." Stanley Street Treatment & Resources, Inc. (SSTAR) is the participating site for this study under the direction of the Site Principal Investigator, Genie L. Bailey, MD. The SSTAR site randomized 81 participants into the study and is now completing remaining study follow-up visits.
The New England Consortium Node also continued participation in the NIDA CTN-0064 study, "Linkage to Hepatitis C Virus (HCV) Care among HIV/HCV Co-Infected Substance Users" enrolling participants from the NIDA CTN-0049 Project HOPE study. The study is being conducted within the node at Boston University Medical Center under the direction of Mari Lynn Drainoni, PhD and Margaret Sullivan, MD, affiliated with the Boston University School of Public Health and the Section of Infectious Diseases through the Boston University School of Medicine. The BU site enrolled 50 participants into the CTN-0064 study.
Researchers from Yale University, Gail D’Onofrio, MD, MS from the Department of Emergency Medicine and David A. Fiellin, MD (General Medicine) are in the process of starting the NIDA CTN-0069 study, "Opioid Use Disorder in the Emergency Department."
Members of the node also participated in a whopping 16 CTN-related publications and 15 CTN-related presentations and dissemination activities. Find a complete list of publications and activities here. . . |
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 From the Addiction Technology Transfer Center Network
Shared Decision Making and Medication-Assisted Treatment: A Supportive Approach to Initiating and Sustaining Addiction Recover -- this month's featured article, by Miriam Komaromy, MD, FACP, FASAM, in the ATTC Messenger.
The latest from the NIATx Service Improvement Blog: National Drug and Alcohol Facts Week, Shattering the Myths, Changing the World's Relationship with Alcohol Through Mobile Technology, and The ATTC Network's Global Reach.
Taking Action to Address Opioid Misuse: Check out this page full of training curricula and slides, online courses, webinars, toolkits, and other resources. Also find links to Pathways to Safer Opioid Use, an interactive training tool from the CDC; SAMHSA's MATx Mobile App for practitioners; and a link to GetNaloxoneNow.org, where you can get training on how to identify and reverse an opioid overdose.
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Webinars, Trainings, Other Events
NIH Priorities for Health Economics Research - Feb. 1, 3pm EST
 Join us for the latest CTN Webinar, NIH Priorities for Health Economics Research, Wednesday, February 1, 2017, from 3-4pm EST.
Sarah Duffy, PhD, of NIDA will discuss NIH priorities for health economics research, providing examples of research likely to meet NIH's health economics priorities and research that likely won't.
Read more here. . .
CTN Steering Committee and Annual Scientific Meeting
 This spring's meeting, March 22-24, 2017, will provide a forum for knowledge exchange of current substance abuse treatment research findings and their policy implications. Topics will cover long-term opioid treatment, management of adolescent substance use disorders (SUDs), applications of mHealth to addiction treatment, Precision Medicine, treatment of HIV-infected patients with SUDs, and integrating substance use research with Practice-Based Research Networks.
Details and registration: http://apps.leedmci.com/nida/ctn/meetings/
Pragmatic and Group-Randomized Trials in Public Health and Medicine Online Course
 This online course, presented by David M. Murray, NIH Associate Director for Prevention and Director of the NIH Office of Disease Prevention, is available for free to all interested parties. The course has 7 modules and includes a list of references, a PDF for each presentation, suggested reading materials, and guided activities.
Read more here. . . |
11th Summer Institute on Alcohol, Drugs and Addiction, July 2017
Amsterdam, The Netherlands
 Participants are now being accepted for the 11th Summer Institute on Alcohol, Drugs and Addiction, to be held at the Graduate School of Social Sciences, University of Amsterdam, July 2-21, 2017.
The program offers graduate students of various disciplines and professions a great opportunity to advance their knowledge in the field of addiction studies in an international environment.
NIDA International is offering two full tuition scholarships for US citizens to attend. The deadline for scholarship applications is March 15, 2017.
Where to apply: http://www.uva.nl/summer-addiction
Deadline: April 15, 2017 (rolling admissions)
Tuition (non-credit): 1350 Euros
Read more here. . .
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Call for Papers for the National Cannabis Summit, August 2017
 If you work in research, policy, public health, public safety, or industry and have compelling data to share about how changing cannabis policy has affected your work or the people you serve, hosts of the upcoming National Cannabis Summit, August 28-30, 2017 (Denver, CO) want to hear from you!
Submit your presentation ideas by March 20, 2017 via this online system.
Summit is sponsored by Advocates for Human Potential, the Addiction Technology Transfer Center Network and the National Council for Behavioral Health.
Read more here . . . |
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 New from the CTN Dissemination Library
CTN-0055 primary outcomes!
Feasibility and Safety of Extended-Release Naltrexone Treatment of Opioid and Alcohol Use Disorder in HIV Clinics: A Pilot/Feasibility Randomized Trial. Korthuis PT, et al. Addiction 2017 (in press). Get article. . .
Predictive Validity of Addiction Treatment Clinicians' Post-Training Contingency Management Skills for Subsequent Clinical Outcomes. Hartzler B, et al. Journal of Substance Abuse Treatment 2017;72:126-133. Get article. . .
Quitting Smoking During Substance Use Disorders Treatment: Patient and Treatment-Related Variables. Campbell BK, et al. Journal of Substance Abuse Treatment 2017; 73:40-46. Get article. . .
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Also of Interest
Health Effects of Cannabis and Cannabinoids: Current State of Evidence & Recommendations for Research. New report from the National Academies of Science presents nearly 100 conclusions related to the health effects of marijuana use, as well as recommendations for an agenda to expand and improve marijuana-related research efforts and better inform public health policymaking. Find the report here.
National Drug & Alcohol Facts Week (NIDA), January 23-29, 2017. National health observance for teens to promote local events that use NIDA science to "Shatter the Myths" about drugs. Learn more. . .
Motivational Interviewing for Clinical Practice. New book references CTN-related research on MI and features several contributors with ties to the CTN as well. Read more. . . |
Upcoming Meetings & Trainings
Addiction Health Services Research 2017. October 18-20, Madison, Wisconsin. Hosted by the University of Wisconsin-Madison School of Medicine & Public Health. Call-for-abstracts coming soon. Read more. . .
CTN Steering Committee and Annual Scientific Meeting. March 22-24, 2017. Register online.
UCLA's Summer Institute on Longitudinal Research and the 2017 International Conference on Global Health, Universal City, California, August 15-17, 2017. Download flyer.
For more upcoming meetings, trainings, and conferences, visit the CTN Dissemination Library's AOD Conferences calendar! |
   
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